Twenty nine stable renal transplant recipients, 10 receiving cyclosporin, 10 cyclosporin-prednisolone and nine azathioprine-prednisolone were supplemented in a double blind randomization cross-over study with fish oil and corn oil for a period of 4 months each. Erythrocyte deformability was reduced in the cyclosporin-treated patients and returned to normal values after supplementation of either oil. The oil supplementation resulted in an increased polyunsaturated fatty acid content in the plasma phospholipids. An increased erythrocyte membrane polyunsaturated fatty acid content might correct the lower erythrocyte deformability in cyclosporin treated patients. Therefore, it is probable that these changes are membrane-related. The oil supplementation had no effect on glomerular filtration rate, effective renal plasma flow, filtration fraction or blood pressure, which does not exclude effects of the cyclosporin-induced rigidified erythrocytes in the acute phase of renal transplantation. Decreased erythrocyte deformability could play a role in the cyclosporin-induced deterioration of renal haemodynamics. This may enhance the effects of endothelin, as these patients also had elevated endothelin levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/00365519309092546 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Examining Erythrocytes as Potential Blood Biomarkers for Autism Spectrum Disorder: Their Relationship to Symptom Severity and Adaptive Behavior.
Biomedicines
November 2024
Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 2, 811 08 Bratislava, Slovakia.
Background: Multiple research teams have documented various abnormalities in erythrocyte properties in children with autism spectrum disorder (ASD) compared with neurotypical individuals. Reduced erythrocyte deformability, a crucial factor for microcirculation and oxygen delivery, may affect brain function. Other key factors like nitric oxide (NO) and Na,K-ATPase-regulated cation transport also play roles in both erythrocyte deformability and ASD, suggesting a possible relationship between erythrocyte parameters and autism severity.
View Article and Find Full Text PDFControlled Coffee Intake Enhances Erythrocyte Deformability, Na,K-ATPase Activity, and GSH/GSSG Ratio in Healthy Young Adults.
Biomedicines
November 2024
Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 2, 811 08 Bratislava, Slovakia.
Background: Published studies suggest that regular coffee consumption may reduce the risk of various diseases. However, many of these studies relied on questionnaire-based data, limiting their ability to identify the specific biological mechanisms behind the observed effects. This study focuses on controlled coffee consumption among healthy young adults to clarify its effects on erythrocyte properties.
View Article and Find Full Text PDFStatin-treated RBC dynamics in a microfluidic porous-like network.
Microvasc Res
March 2025
FluME, Department of Mechanical Engineering, University College London, London, UK; UCL Hawkes Institute, University College London, London, UK. Electronic address:
The impact of therapeutic interventions on red blood cell (RBC) deformability and microscale transport is investigated, using statins as an exemplar. Human RBCs were treated in vitro with two commonly prescribed statins, atorvastatin and rosuvastatin, at clinically relevant concentrations. Changes in RBC deformability were quantified using a microfluidic-based ektacytometer and expressed in terms of the elongation index.
View Article and Find Full Text PDFHydrogen peroxide diffusion across the red blood cell membrane occurs mainly by simple diffusion through the lipid fraction.
Free Radic Biol Med
January 2025
Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, 11400, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, 11800, Uruguay. Electronic address:
Hydrogen peroxide (HO) is an oxidant produced endogenously by several enzymatic pathways. While it can cause molecular damage, HO also plays a role in regulating cell proliferation and survival through redox signaling pathways. In the vascular system, red blood cells (RBCs) are notably efficient at metabolizing HO.
View Article and Find Full Text PDFLight on abnormal red blood cell subpopulations: Label-free optics-based approach for studying in vitro rigidified blood cells.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia. Electronic address:
RBCs deformability plays a crucial role in maintaining proper blood flow and oxygen delivery throughout the body. Conventional ektacytometry fails to differentiate between variations in deformability of RBC subpopulations as the averaging measurement process obscures these differences. In this study, we introduced an approach that integrates label-free optics-based techniques (flow cytometry, phase-contrast, and two-photon excitation fluorescent microscopy) with ektacytometry to evaluate subpopulations that exhibit decreased RBCs deformability upon an in vitro oxidation using 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!