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Background: Meniere's disease (MD) affects 0.2% to 0.5% of the global population, with regional variations.

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Endolymphatic sac tumors (ELSTs) are rare, slow-growing, and locally aggressive neoplasms that originate from the epithelial lining of the endolymphatic duct and sac. These are characterized by their infiltrative growth pattern and the potential for local destruction of surrounding structures, including the inner ear and temporal bone. We report a case of an incidentally diagnosed sporadic ELST.

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Evaluation of Tumor-Infiltrating Leukocytes in Endolymphatic Sac Tumor.

Laryngoscope

January 2025

Department of Otology and Skull Base Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China.

Objective: Endolymphatic sac tumors (ELSTs), as rare low-grade neoplasms, are primarily treated with surgery. This study analyzes the characteristics of tumor-infiltrating leukocytes (TILs) in ELSTs and their relationships with clinical features to explore the potential for immunotherapy in ELSTs.

Methods: Clinical data and tumor specimens of 10 ELSTs patients who underwent surgery were retrieved.

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Circadian rhythm disruptions exacerbate inner ear damage in a murine endolymphatic hydrops model.

FASEB J

January 2025

Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Meniere's disease (MD) is an inner ear disease characterized by endolymphatic hydrops (EH). Maintaining a regular daily routine is crucial for MD patients. However, the relationship between circadian rhythms and MD remains unclear.

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: Spontaneous nystagmus during vertigo attacks of Menière's disease has been essentially described as horizontal, beating ipsilaterally (irritative type) or contralaterally (deficit type) to the hearing loss. Our main objective was to describe the characteristics of nystagmus during vertigo attacks. The second objective was to determine the feasibility of self-video recording of eye movements by a mobile phone.

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