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Cotadutide reversible self-assembly based long-acting injectable depot for sustained delivery of GLP-1 glucagon receptor agonists with controlled burst release.
J Control Release
January 2025
Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Waltham, MA, USA.
Cota is a lipidated dual GLP-1 and Glucagon receptor agonist that was investigated for the treatment of various metabolic diseases, it is designed for once daily subcutaneous administration. Invasive daily injections often result in poor patient compliance with chronic disease, and here, we demonstrate an innovative strategy of encapsulating reversible cota self-assembled fibers within an in-situ forming depot of low molecular weight poly(lactic-co-glycolic) acid (LWPLGA) for sustained delivery GLP-1 and Glucagon receptor agonist with controlled burst release. This could be a suitable alternative to other sustained delivery strategies for fibrillating peptides.
View Article and Find Full Text PDFSegmental analysis of human hair reveals intra-annual variation in 25(OH)D concentrations in modern and archaeological individuals.
Sci Rep
January 2025
The Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, UK.
Vitamin D is essential for healthy skeletal growth and is increasingly recognised for its role in chronic disease development, inflammation and immunity. 25-hydroxyvitamin D (25(OH)D) concentrations are an indicator of vitamin D status and are normally analysed in plasma or serum samples in clinical settings, while archaeological studies rely on the identification of skeletal markers of vitamin D deficiency, such as rickets. Here, we determined 25(OH)D concentrations in hair specimens ('locks') that had been sampled close to the root, aligned by cut end, and sliced into sequential segments from participants (n = 16), from Aberdeen, Scotland, using a modified protocol designed to minimise sample size.
View Article and Find Full Text PDFExposure of insects to current use pesticide residues in soil and vegetation along spatial and temporal distribution in agricultural sites.
Sci Rep
January 2025
iES Landau, Institute for Environmental Sciences, University of Kaiserslautern-Landau, Landau, Germany.
Current use pesticides (CUPs) are recognised as the largest deliberate input of bioactive substances into terrestrial ecosystems and one of the main factors responsible for the current decline in insects in agricultural areas. To quantify seasonal insect exposure in the landscape at a regional scale (Rhineland-Palatine in Germany), we analysed the presence of multiple (93) active ingredients in CUPs across three different agricultural cultivation types (with each three fields: arable, vegetable, viticulture) and neighbouring meadows. We collected monthly soil and vegetation samples over a year.
View Article and Find Full Text PDFTogether throughout the year: seasonal patterns of bacterial and eukaryotic microbial communities in a macrotidal estuary.
Environ Microbiome
January 2025
Université de Caen Normandie, Laboratoire MERSEA UR 7482, Centre de Recherches en Environnement Côtier, 14530, Luc-sur-Mer, France.
Background: Estuaries are complex ecosystems linking river and marine environments, where microorganisms play a key role in maintaining ecosystem functions. In the present study, we investigated monthly 8 sites at two depth layers and over a one-year period the bacterial and eukaryotic community dynamics along the Seine macrotidal estuary (Normandy, France). To date, the taxonomy of the microbial diversity present in this anthropized estuary remains elusive and the drivers of the microbial community structure are still unknown.
View Article and Find Full Text PDFA long-term analysis of oxidant (OX = O + NO) and its local and regional levels in Tehran, Iran, a high NO-saturated condition.
Sci Rep
January 2025
Department of Civil and Environmental Engineering, Amirkabir University of Technology (Tehran Polytechnic), 350 Hafez Avenue, Tehran, 159163-4311, Iran.
Oxidant (OX), the sum of ozone (O) and nitrogen dioxide (NO), is used to determine nitrogen oxides (NO)-independent regional contribution and NO-dependent local contribution. This study investigates OX trends and its local and regional levels in Tehran, Iran using the data from 21 monitoring stations from 2012 to 2022 and satellite remote sensing data (TROPOMI) for 2022. The spatiotemporal trends of O, NO, and OX are first examined using ground-based and remote sensing data, and then the polar plots are employed to identify the dominant directions of OX transport and its sources.
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