1. The effects of lead poisoning during pregnancy were tested on female Sprague-Dawley rats that inhaled 5 mg m-3 lead oxide for 13 days during gestation. At the end of gestation, the respective blood lead levels of dams and fetuses were 71.1 and 83.2 micrograms 100 ml-1, indicating lead poisoning. 2. In the 90 day-old male offspring of the exposed dams, testis weight and histology, and epididymal weight and sperm reserve, were all similar to those of control males. Spermatozoa mobility and morphology were normal. 3. Also similar to control values were the pituitary weight in these male offspring, their plasma FSH, LH and testosterone levels, and the weight of their ventral prostate and seminal vesicles, the targets of the sexual hormones. 4. When male and female offspring of exposed dams were mated, their fertility was normal, with no increase in prenatal death or malformations, and no changes in the size or sex ratio of litters. 5. These results indicate that, under our experimental conditions, lead oxide inhalation by rats during pregnancy did not perturb reproductive function in their male offspring.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/096032719401300403 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Les Cartes Porcelaine of the Mid 19th Century.
J Hist Dent
January 2025
Clinic Director, Cavity Busters Doylestown, Doylestown, PA Adjunct Professor Pediatric Dentistry University of Texas HSC at San Antonio Clinical Professor, Pediatric Dentistry Case Western Reserve School of Dental Medicine.
A unique type of advertising trade card was popular in Europe, mostly Belgium, between 1840 and 1865. These cards were produced with a coating of a white lead substance that gave them a lustrous appearance and feel, resembling porcelain. As attractive as these cards were, producing them oftentimes resulted in lead poisoning for the printers, so few were produced after 1865.
View Article and Find Full Text PDFCausal Mediation Analysis of Foodborne Outbreaks in the United States: Serotypes and Food Vehicles.
Pathogens
December 2024
Department of Food Science, Center for Food Safety, University of Arkansas System Division of Agriculture, Fayetteville, AR 72704, USA.
Various serotypes have caused numerous foodborne outbreaks associated with food vehicles in different categories. This study provides evidence on the occurrence and inter-relations between serotypes and the number of deaths mediated by the number of illnesses and hospitalizations. Confirmed foodborne outbreaks of serotypes (n = 2868) that occurred between 1998 and 2021 were obtained from the Centers for Disease Control and Prevention National Outbreak Reporting System.
View Article and Find Full Text PDFAwareness and Knowledge of Lead Poisoning: A Street Survey in Three Municipalities of Georgia.
Int J Environ Res Public Health
December 2024
Ilia State University, Tbilisi 0162, Georgia.
Lead poisoning is a serious public health problem, especially for children. Despite screening programs to reduce lead exposure, there is still a lack of knowledge about its harmful impact. The study aimed to analyze how aware people in Georgia are about lead poisoning and its health effects.
View Article and Find Full Text PDFPan-European atmospheric lead pollution, enhanced blood lead levels, and cognitive decline from Roman-era mining and smelting.
Proc Natl Acad Sci U S A
January 2025
Institute of Archaeology, University of Oxford, Oxford OX1 4PG, United Kingdom.
Ancient texts and archaeological evidence indicate substantial lead exposure during antiquity that potentially impacted human health. Although lead exposure routes were many and included the use of glazed tablewares, paints, cosmetics, and even intentional ingestion, the most significant for the nonelite, rural majority of the population may have been through background air pollution from mining and smelting of silver and lead ores that underpinned the Roman economy. Here, we determined potential health effects of this air pollution using Arctic ice core measurements of Roman-era lead pollution, atmospheric modeling, and modern epidemiology-based relationships between air concentrations, blood lead levels (BLLs), and cognitive decline.
View Article and Find Full Text PDFClinical manifestation and laboratory data of illicit drugs versus other substances intoxication in children.
Sci Rep
January 2025
Golestan Research Center of Gastroentrology and Hepatology & Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Children are highly sensitive to toxins which can damage their organs and lead to death. Investigating the main causes of intoxication could reduce mortality and morbidity in children. In this cross-sectional study, the documents of all poisoned patients (214 cases) admitted to the emergency department of Taleghani children`s Hospital between April 2020 and 2023 were investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!