Nine paranoic schizophrenia patients and nine controls participated in the study aimed at revealing differences in their ability to discover a pattern of auditory stimuli and to react to changes in environmental probability structure. Two kinds of auditory stimuli were used: high--1200 Hz (H) and low--800 Hz (L), both of 50 msec duration and 60 dB intensity. The experimental series were: series 1 (S1)--simple motor reaction to 50 L tones; series 2 (S2) and series 3 (S3) were identical--a cycle signal pattern (HHLHLL) of 102 tones. In S2 the instruction required choice motor reaction to L tone and in S3, also discovering the tone sequence and its verbal announcement. Patients discovered the stimulus pattern at the 28th and controls at the 30th signal. RT of patients in all series was longer than that of controls. Each of the factors "group" (controls/patients) and "experimental series" had a significant influence on RT. The possibility of interpreting these results as connected with an extrasensor mechanism dysfunction is discussed.
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Efficient visual word recognition presumably relies on orthographic prediction error (oPE) representations. On the basis of a transparent neurocognitive computational model rooted in the principles of the predictive coding framework, we postulated that readers optimize their percept by removing redundant visual signals, allowing them to focus on the informative aspects of the sensory input (i.e.
View Article and Find Full Text PDFCerebrospinal fluid (CSF) dynamics, driven by sensory stimulation-induced neuronal activity, is crucial for maintaining homeostasis and clearing metabolic waste. However, it remains unclear whether such CSF flow is impaired in age-related neurodegenerative diseases of the visual system. This study addresses this gap by examining CSF flow during visual stimulation in glaucoma patients and healthy older adults using functional magnetic resonance imaging.
View Article and Find Full Text PDFThe idea of self-organized signal processing in the cerebral cortex has become a focus of research since Beggs and Plentz reported avalanches in local field potential recordings from organotypic cultures and acute slices of rat somatosensory cortex. How the cortex intrinsically organizes signals remains unknown. A current hypothesis was proposed by the condensed matter physicists Bak, Tang, and Wiesenfeld when they conjectured that if neuronal avalanche activity followed inverse power law distributions, then brain activity may be set around phase transitions within self-organized signals.
View Article and Find Full Text PDFImaging Neurosci (Camb)
April 2024
Department of Electrical Engineering, Columbia University, New York, NY, United States.
Listeners with hearing loss have trouble following a conversation in multitalker environments. While modern hearing aids can generally amplify speech, these devices are unable to tune into a target speaker without first knowing to which speaker a user aims to attend. Brain-controlled hearing aids have been proposed using auditory attention decoding (AAD) methods, but current methods use the same model to compare the speech stimulus and neural response, regardless of the dynamic overlap between talkers which is known to influence neural encoding.
View Article and Find Full Text PDFNeurophotonics
January 2025
Northeastern University, Department of Bioengineering, Boston, Massachusetts, United States.
Significance: Functional brain imaging experiments in awake animals require meticulous monitoring of animal behavior to screen for spontaneous behavioral events. Although these events occur naturally, they can alter cell signaling and hemodynamic activity in the brain and confound functional brain imaging measurements.
Aim: We developed a centralized, user-friendly, and stand-alone platform that includes an animal fixation frame, compact peripheral sensors, and a portable data acquisition system.
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