Coal tar, a tumour initiator, and dithranol, a tumour promoter, are used in the treatment of psoriasis. Topical treatment of mice with pharmaceutical formulations of these two agents, at therapeutic doses, induced skin papillomas in a classical two-stage carcinogenesis protocol, while treatment with either agent alone did not. This finding has implications for the use of both agents in combination in the treatment of psoriasis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1969454 | PMC |
| http://dx.doi.org/10.1038/bjc.1994.205 | DOI Listing |
Publication Analysis
Top Keywords
treatment psoriasis
8
tumorigenicity combination
4
combination psoriasis
4
psoriasis therapies
4
therapies coal
4
coal tar
4
tar tumour
4
tumour initiator
4
initiator dithranol
4
dithranol tumour
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!