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The pharmacokinetics of quinapril and quinaprilat in patients with congestive heart failure. | LitMetric

The pharmacokinetics of quinapril and its active metabolite quinaprilat were studied in 12 patients with congestive heart failure (CHF) after multiple oral doses of 10 mg quinapril twice daily. Six patients had an ejection fraction of < 35% and six had an ejection fraction between 35%-50%. Increases in the apparent elimination half-life and in AUC(0, 12h) values of quinaprilat were associated with smaller ejection fractions, decreased creatinine clearance, and increased patient age. Comparison with data from age-matched controls having comparable renal function suggests that creatinine clearance is the major determinant of quinaprilat clearance. CHF per se appears to have minimal effect. Dosing of quinapril in patients with CHF should be based on their renal function.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364764PMC
http://dx.doi.org/10.1111/j.1365-2125.1994.tb04280.xDOI Listing

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