One case of myo-epithelioma occurring in the parotid gland is reported. This tumor was composed of spindle cells. The diagnosis was confirmed by ultrastructural and immunohistochemical analysis demonstrating myofilaments aggregation pattern and positive staining for S100-protein and keratin antibodies. Of all salivary gland tumors, myo-epithelioma accounts for less than 1% of the total and has a good prognosis. Conservative surgical management is curative.
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