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[Changes and clinical significance of erythrocyte lifespan in megaloblastic anemia].
Zhonghua Nei Ke Za Zhi
June 2023
Department of Hematology, Lanzhou University Second Hospital, Key Laboratory of Hematology in Gansu Province, National Hematology Clinical Medical Research Center of Gansu Province (Gansu Hematology Clinical Medical Research Center), Lanzhou 730030, China.
To investigate the lifespan of erythrocytes in megaloblastic anemia (MA) patients. A prospective cohort study analysis. Clinical data from 42 MA patients who were newly diagnosed at the Department of Hematology, Lanzhou University Second Hospital from January 2021 to August 2021 were analyzed, as were control data from 24 healthy volunteers acquired during the same period.
View Article and Find Full Text PDFAcquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection.
Nutrients
October 2022
Hereditary Metabolic Disease Reference Center, Metabolic Unit, Pediatric Department, Santa Maria's Hospital-Lisbon North University Hospital Center, EPE, Pediatric University Clinic, Faculty of Medicine, University of Lisbon, 1600-190 Lisbon, Portugal.
The early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency's functional biomarkers.
View Article and Find Full Text PDFHow I investigate acquired megaloblastic anemia.
Int J Lab Hematol
April 2022
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
In this review of megaloblastic anemia (MA), an overview of vitamin B and folate body requirements, biochemical pathways, and laboratory testing strategies will be provided. However, the focus of this review is the classic and unique features of MA in blood and bone marrow. Acquired MA is a benign disorder for many, but can be detrimental for some.
View Article and Find Full Text PDFUnderstanding Sideroblastic Anemia: An Overview of Genetics, Epidemiology, Pathophysiology and Current Therapeutic Options.
J Blood Med
September 2020
Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA.
Sideroblastic anemia (SA) consists of a group of inherited and acquired anemias of ineffective erythropoiesis characterized by the accumulation of ring sideroblasts in the bone marrow due to disrupted heme biosynthesis. Congenital sideroblastic anemia (CSA) is rare and has three modes of inheritance: X-linked (XLSA), autosomal recessive (ARCSA), and maternal. Acquired SA is more common and can be a result of myelodysplastic syndromes (MDS) or other, generally reversible causes.
View Article and Find Full Text PDFViral metagenomics reveals diverse anelloviruses in bone marrow specimens from hematologic patients.
J Clin Virol
November 2020
Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China. Electronic address:
Background: An infectious etiology has been proposed for many human cancers, but rarely have specific agents been identified. Viral metagenomic technique is useful for identification of viral pathogens potentially existing in bone marrow specimens from hematologic patients.
Methods: A total of 24 patients were included in this study, including 14 female (58.
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