Objective: To determine the ability of interleukin 10 (IL-10) to suppress postoperative intraperitoneal adhesion formation.
Design: Randomized, controlled trial.
Setting: University animal research facility.
Animals: Six-week-old Swiss Webster mice undergoing a standardized intraperitoneal operative procedure.
Interventions: Animals were randomized to "surgery" or "no surgery" and then further randomized to receive intraperitoneal injections of 1 mL phosphate-buffered saline (PBS) or 1 microgram/kg IL-10 in 1 mL PBS. Vehicle-only doses were given immediately after surgery and then every 24 hours for a total of four injections. Interleukin 10 injections were similarly given but with an added preoperative injection 30 minutes before surgery in one half of the animals.
Main Outcome Measure: Adhesion formation.
Results: Animals treated with vehicle or IL-10 but not undergoing surgical intervention had no intraperitoneal adhesions. Animals undergoing surgery who were treated with IL-10, with or without a preoperative dose, had significantly lower postoperative adhesion scores than did control animals who postoperatively received PBS only.
Conclusion: Interleukin-10 is effective at limiting postoperative intraperitoneal adhesion formation with minimal evident systemic side effects.
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