Mice F1 (CBA x C57Bl) life span after transplantation of standard number of leukemia EL-4 cells at different clock hours was evaluated. At the same time, as injection was done, rectal temperature of mouse was measured. Both parameters showed circadian trend. Mice life span was in negative correlation with rectal temperature. So it is possible to consider temperature rhythm as marker rhythm of natural antitumor resistance.
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