The authors generalized the experience of interference current apparatus application for the treatment of acute disease and trauma in the N.V. Sklifosovsky Scientific and Research Institute for Emergency Medicine (Moscow). A kind of recorder for reading the interfinger electric resistance of patient skin was offered as a biologic feedback to this apparatus aimed at individualized treatment. The values of the "resonance" frequencies shown by the recorder of the biological feedback to the interference current apparatus allow to determine the duration of the refractivity of excitable membranes in patients in the process of the complex treatment.
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Biosens Bioelectron
January 2025
Department of Chemistry, Kansas State University, Manhattan, KS, 66502, USA. Electronic address:
Proteases are overexpressed at various stages of conditions such as cancers and thus can serve as biomarkers for disease diagnosis. Electrochemical techniques to detect the activity of extracellular proteases have gained attraction due to their multiplexing capability. Here we employ an electrochemical approach based on a 3 × 3 gold (Au) microelectrode array (MEA) functionalized with (2-aminoethyl)ferrocene (AEF) tagged specific peptide substrates to monitor cathepsin B (CB) protease activity.
View Article and Find Full Text PDFJ Med Ethics
January 2025
Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Introduction: The integration of artificial intelligence (AI) into healthcare introduces innovative possibilities but raises ethical, legal and professional concerns. Assessing the performance of AI in core components of the United States Medical Licensing Examination (USMLE), such as communication skills, ethics, empathy and professionalism, is crucial. This study evaluates how well ChatGPT versions 3.
View Article and Find Full Text PDFVirchows Arch
January 2025
Department of Pathology, Stanford Medical Center, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Beyond the more common TFE3 fusion partners PRCC, ASPSCR1, and SFPQ, additional less common fusion partners of TFE3-rearranged renal cell carcinoma (RCC) have been described. Herein, we present an example of TFE3-rearranged renal cell carcinoma harboring fusion partner MAPK1IP1L, a rare rearrangement with only one other reported tumor found in the literature. The currently reported TFE3-rearranged RCC demonstrates unique histological features compared to the previously reported tumor including dense eosinophilic cytoplasm and nuclear pseudoinclusions (corroborated by electron microscopic evaluation), with features not typically seen in other TFE3-rearranged RCCs.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
infections continue to pose a significant global health challenge, particularly due to the rise of multidrug-resistant strains, random mycobacterial mutations, and the complications associated with short-term antibiotic regimens. Currently, five approved drugs target cell wall biosynthesis in . This review provides a comprehensive analysis of these drugs and their molecular mechanisms.
View Article and Find Full Text PDFSensors (Basel)
January 2025
School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Accurately measuring the thickness of the oxide film that accumulates on nuclear fuel assemblies is critical for maintaining nuclear power plant safety. Oxide film thickness typically ranges from a few micrometers to several tens of micrometers, necessitating a high-precision measurement system. Eddy current testing (ECT) is commonly employed during poolside inspections due to its simplicity and ease of on-site implementation.
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