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The Role of Simpson Grading System in Spinal Meningioma Surgery: Institutional Case Series, Systematic Review and Meta-Analysis.
Cancers (Basel)
December 2024
Neurosurgery Department, Santa Maria delle Grazie Hospital, ASL Napoli 2 Nord, Via Domitiana Località La Schiana Pozzuoli, 80078 Naples, Italy.
Background: Although its validity has recently been questioned since its introduction, the Simpson grade has remained one of the most relevant factors in estimating the recurrence risk of intracranial meningiomas. This study aims to assess its role in spinal meningiomas through a retrospective analysis of a mono-institutional surgical series and literature meta-analysis.
Methods: We conducted a systematic review and meta-analysis of the literature from 1980 to 2023, complemented by a mono-institutional series of 74 patients treated at "Santa Maria delle Grazie" hospital.
MYCN-amplified spinal ependymomas: a rare aggressive subtype. Illustrative cases.
J Neurosurg Case Lessons
January 2025
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Background: Spinal ependymomas are typically slow-growing tumors with a favorable prognosis. Recently, a new aggressive subtype has emerged with its own distinct histopathological and molecular features characterized by MYCN amplification. However, this subtype of spinal ependymoma is rare, and studies on its imaging characteristics are limited.
View Article and Find Full Text PDFA 68-year-old patient came to the emergency department complaining of headaches and general weakness for the past month. The patient is known to have myeloproliferative disease. Non-contrast computer tomography showed a hyperdense extra-axial collection in bilateral frontoparietal regions, which was presumed to be bilateral subdural hematoma as the initial diagnosis.
View Article and Find Full Text PDFChloroma of the Cerebellopontine Angle: A Rare Presentation.
World Neurosurg
December 2024
Department of Radiology, CHC UFPR (Complexo Hospital de Clínicas da Universidade Federal do Paraná), Curitiba, Brazil.
This article presents a case study of a 7-year-old female patient with a history of acute myelogenous leukemia, previously treated with chemotherapy. The patient developed acute right peripheral facial paralysis and right upper limb weakness, leading to the discovery of an extra-axial solid lesion at the right cerebellopontine angle. This lesion extended into adjacent structures with notable contrast enhancement and restricted diffusion on magnetic resonance imaging, indicative of chloroma, an extramedullary solid mass composed of myeloid precursor cells.
View Article and Find Full Text PDFIntracranial Myeloid Sarcoma Arising Intra-axially From Acute Myeloid Leukemia: A Case Report and Literature Review.
Cureus
August 2024
Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, JPN.
Article Synopsis
- * Imaging revealed a mass in the right cerebellum, and subsequent surgical resection showed the tumor's characteristics included small round cells and signs of macrophage invasion, highlighting its connection to the AML.
- * The case emphasizes the importance of considering intracranial myeloid sarcoma in patients with a history of hematological cancers like AML, despite challenges in differentiating tumor types through imaging.
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