AI Article Synopsis
- Rats were trained to distinguish between the opioid receptor agonist ethylketocyclazocine (EKC) and saline, with findings showing that interferon-alpha (IFN-alpha) can produce similar EKC-like responses.
- Administration of the opioid antagonist naloxone blocked these responses, indicating that the effects of IFN-alpha involve opioid neurons.
- Additionally, results showed that d-amphetamine enhances responses to both EKC and IFN-alpha, supporting the idea of an opioid-mediated dopaminergic mechanism in the action of IFN-alpha.
Article Abstract
Rats were trained to discriminate the opioid receptor agonist ethylketocyclazocine (EKC) (0.3 mg/kg body weight, intraperitoneally) from saline. Interferon-alpha (IFN-alpha), when substituted for EKC, elicited a dose-related increase in EKC-like responses. This generalization of EKC responses was blocked by the opioid antagonist naloxone (1 mg/kg). Potentiation of responses to a low dose (0.1 mg/kg) of EKC by IFN-alpha (1 x 10(6) U/kg or 0.22 nmol/kg) was also observed. Data thus indicate the involvement of opioid neurons on the action of IFN-alpha. d-Amphetamine (0.8 mg/kg) was shown to potentiate both EKC (0.1 mg/kg) and IFN-alpha (1 x 10(6) U/kg). The present study confirms our previously proposed opioid-mediated dopaminergic mechanism of IFN-alpha.
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| http://dx.doi.org/10.1097/00001813-199402000-00014 | DOI Listing |
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