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Background: Cognitive impairment and attention deficit disorder have been on the rise among generations in recent times. A significant portion of the brain involved in learning and cognition is the hippocampus. Its development begins in utero till weaning.

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Exposure to Perinatal Trauma Modifies Nociception and Gene Expression in the Prefrontal Cortex and Hypothalamus of Adolescent Rats.

J Pain

December 2024

Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address:

The perinatal period encompasses a critical window for neurodevelopment that renders the brain highly responsive to experience. Trauma, such as intimate partner violence (IPV) and early life stress/neglect, during this period negatively affects physical and mental health outcomes, including increasing ones risk for chronic pain. Although epigenetic programming likely contributes, the mechanisms that drive the relationship between perinatal trauma and adverse health outcomes, are not fully understood.

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Maternal and Infant Health Outcomes in US-Born and Non-US-Born Black Pregnant People in the US.

JAMA Netw Open

December 2024

Center of Excellence in Maternal, Child and Adolescent Health, University of California, Berkeley.

Importance: With disparate Black maternal health outcomes in the US and a steadily expanding non-US-born Black population, it is beneficial to investigate Black maternal health outcomes by country of origin.

Objective: To compare the prevalence of maternal morbidity and infant birth outcomes between US-born and non-US-born Black populations in the US.

Design, Setting, And Participants: This cross-sectional study included all registered hospital births in the US from the 2021 National Vital Statistics Systems (NVSS) Natality Data.

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Autonomic dysfunction is associated with cardiovascular and neurological disease, including hypertension, heart failure, anxiety, and stress-related disorders. Prior studies demonstrated that late gestation exposure to dexamethasone (DEX) resulted in female-biased increases in stress-responsive mean arterial pressure (MAP) and heart rate (HR), suggesting a role for glucocorticoid-mediated programming of autonomic dysfunction. The present study investigated the influence of sympathetic (SYM) or parasympathetic (PS) blockade on cardiovascular function in male and female rat offspring of mothers injected with DEX (gestation days [GD]18-21).

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