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http://dx.doi.org/10.1001/archderm.130.5.665 | DOI Listing |
Biosensors (Basel)
April 2023
Department of Molecular and Biomolecular Physics, National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293 Cluj-Napoca, Romania.
J Pharm Sci
December 2019
Department of Drug Sciences, University of Catania, Catania, Italy.
This review addresses a major question of importance to pharmaceutical scientists: how can novel drug delivery systems play a role in maximizing the UV protection of sunscreens? Because more and more people are being diagnosed with skin cancer each year than all other cancers combined, adequate sun protective measures are pivotal. In this context, the present review is to give an up-to-date overview on the different nanocarrier systems that have been explored so far for encapsulating different types of UV filters present on the market. The aim of these carrier systems is to prevent skin penetration and to enhance the photoprotective potential of sunscreen actives.
View Article and Find Full Text PDFAm J Dermatopathol
July 2016
*Department of Anatomical Pathology, PathWest, QEII Medical Centre, Nedlands, Australia; and †School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Western Australia, Australia.
As ultraviolet radiation is an important aetiological agent in melanoma development, the presence of solar elastosis is an important factor in the assessment of any melanocytic lesion. However, melanocytic naevi are also seen in chronically sun damaged skin, particularly in regions with high levels of ultraviolet exposure and fair skinned populations. It has previously been noted that the relationship of a melanocytic proliferation to elastic fibers in the dermis can be of discriminatory value in the separation of melanoma from melanocytic naevus, in particular, it has been proposed that naevi act as a "sunscreen," which may result in a histological clue that the authors colloquially refer to in practice as "the umbrella sign.
View Article and Find Full Text PDFPhotodermatol Photoimmunol Photomed
October 2014
Department of Dermatological Research, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
We present research on sunscreen use with possible pitfalls and discuss theory vs. reality. A literature review in PubMed was conducted using the terms 'sunscreen application', 'sunscreen use' and 'sun protection factor'.
View Article and Find Full Text PDFMethods Mol Biol
May 2014
Department of Molecular Systems Biology, University of Vienna, Vienna, Austria.
In eukaryotic cells many diverse cellular functions are regulated by reversible protein phosphorylation. In recent years, phosphoproteomics has become a powerful tool to study protein phosphorylation because it allows unbiased localization, and site-specific quantification, of in vivo phosphorylation of hundreds of proteins in a single experiment. A common strategy to identify phosphoproteins and their phosphorylation sites from complex biological samples is the enrichment of phosphopeptides from digested cellular lysates followed by mass spectrometry.
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