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Goodpasture syndrome: a rare case presenting with recurrent haemoptysis.
BMJ Case Rep
January 2024
Radiodiagnosis, Shri Sathya Sai Medical College and Research Institute, Chengalpattu, Tamilnadu, India.
is a rare autoimmune disease which affects young adults with a male preponderance and can be triggered at any point in life with a classical clinical triad of rapidly progressive glomerulonephritis, diffuse pulmonary haemorrhage and circulating anti-glomerular basement membrane antibody (anti-GBM antibody). Here we are presenting a case of a young man with hypertension in his early 20s who presented with fatigue, recurrent haemoptysis, breathlessness and decreased urine output without features of infection. He was diagnosed at an early stage of the disease with the help of clinical, serological and radiological findings.
View Article and Find Full Text PDFAn Unusual Case of Anti-Glomerular Basement Membrane Disease and Phospholipase A Receptor-Associated Membranous Nephropathy After Exposure to Hydrocarbons.
Am J Kidney Dis
January 2024
Department of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
We present a rare case of a patient with toluene exposure manifesting as anti-glomerular basement membrane (GBM) disease on a background of phospholipase A receptor (PLAR)-associated membranous nephropathy. A 23-year-old man presented to the emergency department with hypertension, headache, hemoptysis, anemia, acute kidney injury, glomerular hematuria, and proteinuria. He endorsed repeated exposure to toluene-containing products while repairing dirt bikes.
View Article and Find Full Text PDFCase report: A study on the variant of Kabuki syndrome with Goodpasture's syndrome by whole exome sequencing.
Front Pediatr
August 2022
Department of Respiration, Children's Hospital of Fudan University, Shanghai, China.
Kabuki syndrome (KS) is a rare genetic disorder characterized by dysmorphic facial features, skeletal abnormalities, and intellectual disability. and were identified as the main causative genes. To our knowledge, there exist no cases of KS, which were reported with pneumorrhagia.
View Article and Find Full Text PDFAnti-Glomerular Basement Membrane Nephritis Potentially Induced by Nebulized Tobramycin Inhalation.
J Aerosol Med Pulm Drug Deliv
April 2022
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
To describe a case of anti-glomerular basement membrane (GBM) nephritis that occurred shortly after initiation of nebulized tobramycin (TOB) therapy using intravenous solution, suggesting an association with the inhalation therapy and the disease onset. With the emergence of antimicrobial resistance, clinical importance of aminoglycosides that usually remain susceptibility against gram-negative organisms is increasingly acknowledged. Despite the growing number of evidence supporting the effectiveness of aminoglycoside inhalation therapy for respiratory tract infections, its clinical application has yet to be widely approved by Japanese health insurance.
View Article and Find Full Text PDFRecurrent, Atypical Anti-Glomerular Basement Membrane Disease.
Indian J Nephrol
April 2021
Nephrology Service, Bendigo, Monash University Rural School of Health, Bendigo, Victoria, Western Australia.
Anti-glomerular basement membrane disease (GBM) (Goodpasture's disease) typically presents with acute manifestations of rapidly progressive glomerulonephritis often accompanied by lung haemorrhage. Anti-GBM disease is usually monophasic. However, atypical presentations with indolent renal involvement are being increasingly recognized.
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