One hundred and eighty eight pairs of mother--newborn was examinated. Cytotoxic anti-HL-A antibodies were found in 21% of mothers and 16, 5% of newborns. In 70% the mother's anti-HL-A antibodies passed in the foetus circulation. Authors did not found the damage of the foetus connected with the presence of anti-HL-A antibodies. We did not observe the corellation between the compatibility of antigens ABO and Rh Blood groups of mother and foetus, and the apparence of cytotoxic anti-HL-A antibodies. In the paiss A-B and O-B cytotoxic anti HL-A antibodies were present in significant high percent.
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When in a patient who is receiving random donor platelet infusions there is an inadequate rise in platelet count and anti-human HL-A antibodies are noted in the serum, it is natural to assume that platelet destruction results from an immunologic cause. Nonimmunologic causes of such failure do occur, however. Two of the most common are disseminated intravascular coagulation and splenomegaly.
View Article and Find Full Text PDFFrom June, 1970, to January, 1975, 399 first transplants were performed at the University of Minnesota. Of these 399, 52 had performed antibodies against HLA antigens. When the results of transplantation to these recipients were compared with the results of transplantation to a recipient group matched for age, sex, presence of diabetes, time of transplant, and donor type, no differences were observed.
View Article and Find Full Text PDFHistocompatibility antigen was analyzed in 1,104 patients with trophoblastic neoplasia and in their husbands. Furthermore, the patients were examined for cell-mediated immunity. (1) There was no significant difference in the frequency of the ABO blood groups between patients with hydatidiform or destructive mole or choriocarcinoma and healthy persons.
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