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The effects of hemodialysis on the cardiovascular system.
Semin Vasc Surg
December 2024
Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, BCM 390, Houston TX 77030.
Chronic kidney disease and dialysis-dependent end-stage renal disease are increasing in prevalence in the United States. The costs associated with end-stage renal disease management comprise approximately 1% of the federal government's annual budget. Chronic kidney disease and end-stage renal disease cause significant derangements of the cardiac and vascular system.
View Article and Find Full Text PDFMetabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy.
ESC Heart Fail
November 2024
Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Background And Aims: The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
View Article and Find Full Text PDFIncreased Susceptibility of Cardiac Tissue to PM-Induced Toxicity in Uremic Cardiomyopathic Rats Is Linked to Elevated Levels of Mitochondrial Dysfunction.
Environ Toxicol
October 2024
Vascular Biology Lab, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.
Patients with chronic kidney disease (CKD) frequently develop uremic cardiomyopathy, characterized by mitochondrial dysfunction as one of its pathologically significant mediators. Given that PM specifically targets cardiac mitochondria, exacerbating toxicity, this study addresses the potential alterations in the severity of PM toxicity in the context of CKD conditions. Female Wistar rats were exposed to PM at a concentration of 250 μg/m daily for 3 h for 21 days after which an adenine-induced CKD model was developed.
View Article and Find Full Text PDFLanadelumab in a kidney transplant patient with hereditary angioedema due to C1-inhibitor deficiency and high cardiovascular risk - a case report.
Front Immunol
October 2024
Internal Medicine Department, Fatebenefratelli Hospital, Milan, Italy.
Article Synopsis
- Cardiovascular diseases are the leading cause of death in patients with hereditary angioedema due to C1-inhibitor deficiency (HAE-C1INH), often exacerbated by long-term treatments like attenuated androgens that can increase cardiovascular risk.
- A case study of a 56-year-old HAE-C1INH patient with numerous health issues, including kidney impairment and hypertension, showcased a successful transition from traditional androgen therapy to the modern treatment, lanadelumab, starting in 2020.
- After beginning lanadelumab, the patient saw no angioedema attacks, experienced a decrease in cardiovascular risk factors like cholesterol and body mass index, and improved overall health outcomes, indicating this treatment's effectiveness and safety.
[The current diagnosis and treatment situation of rare disease in the pediatric intensive care unit].
Zhonghua Er Ke Za Zhi
October 2024
Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Article Synopsis
- A study looked at 105 kids with rare diseases who were treated in the PICU at Beijing Children's Hospital from January 2020 to December 2022, focusing on their ages and types of diseases.
- The most common diseases found were problems related to hormones, nutrition, and metabolism, with a few cases of brain and genetic issues.
- Among the kids, the average age was about 5 years old, and most of them were boys; the researchers also noted that different age groups had different common diseases.
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