This is a report of a successful pregnancy on a patient that had congenital vaginal aplasia with a functioning uterus. Continuity of the reproductive tract was restored at 12 years of age with transplantation of vaginal wall from the mother. The patient had no problems after initiating intercourse 7 years later and conceived without treatment after 5 years of primary infertility. She was delivered by cesarean section at term.
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Sci Rep
January 2025
Laboratory of Integrative Neuroscience (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil.
Maternal adverse childhood experiences (ACEs) are linked to negative health and developmental outcomes in offspring. However, whether maternal ACEs influence infant weight gain in the first months of life, and if this effect differs by infant sex, remains unclear. This study included 352 full-term newborns from low-risk pregnancies and their mothers in low-income settings in Brazil.
View Article and Find Full Text PDFJ Matern Fetal Neonatal Med
December 2025
Neonatal Intensive Care Unit, G d'Annunzio University of Chieti, Italy.
Background: Adrenomedullin (AM) is a potent angiogenic, antioxidant and anti-inflammatory peptide protecting the developing lung from injury due to bronchopulmonary dysplasia (BPD) of the preterm infant. At this stage, no data on the potential effects of chorioamnionitis (CA) occurrence and glucocorticoids (GC) administration on AM in developing lungs are still lacking.
Objective: to investigate, in a sheep-based model, the positive/side-effects of combined exposure to CA and GC on AM concentrations measured in bronchoalveolar lavage fluid (BALF).
Am J Obstet Gynecol
January 2025
Department of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center, Cleveland OH; Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH. Electronic address:
Background: The use of glucagon-like-peptide-1 receptor agonists (GLP-1RAs) has greatly increased in patients of reproductive age within the past four years. However, there is minimal research into the long-term impact of these medications on future pregnancies.
Objectives: We aimed to evaluate the association between adverse obstetric outcomes and antecedent GLP-1RA use using a nationally representative database.
Placenta
January 2025
Mother Infant Research Institute, Tufts Medicine, Boston, MA, USA; Dept Obstetrics & Gynecology, Tufts University, Boston, MA, USA. Electronic address:
Hypothesis: Declines in insulin sensitivity during pregnancy important for fetal growth are associated with impairments in skeletal muscle post-receptor insulin signaling. The primary initiator of these changes is unknown but believed to originate in the placenta. We hypothesize that placental miRNAs are associated with maternal sensitivity changes and impact insulin-sensitive mechanisms in target tissues in vitro.
View Article and Find Full Text PDFJACC Heart Fail
January 2025
Center for Primary Health Care Research, Department of Clinical Sciences, Lund University, Malmö, Sweden; University Clinic Primary Care Skåne, Region Skåne, Sweden.
Background: Adverse pregnancy outcomes, such as preterm delivery and hypertensive disorders of pregnancy, may be associated with higher future risks of heart failure (HF). However, the comparative effects of different adverse pregnancy outcomes on long-term risk of HF, and their potential causality, are unclear.
Objectives: The authors sought to examine 5 major adverse pregnancy outcomes in relation to long-term risk of HF in a large population-based cohort.
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