AI Article Synopsis
- The study analyzed CEA levels in 93 patients with confirmed large bowel tumors using a new radioimmunoassay method.
- Approximately 37-40% of preoperative serum samples were normal, while one third showed intermediate levels, and 26-28% had high pathological levels of CEA.
- Post-surgery, patients with localized tumors showed improvement in CEA levels, while those with metastases experienced worsening or high levels of CEA.
Article Abstract
Specimens from 93 patients with histologically confirmed tumors of the large bowel (53 single, 40 sequential determinations) were investigated by a new CEA radioimmunoassay (double antibody method, direct serum determination). Of the single and preoperative sequential determinations 37-40% were normal (below 2.5 ng/ml), one third was intermediately elevated (2.6-15 ng/ml) and 26-28% were highly pathological leveled (over 15 ng/ml). Following operation, cases with local or regionally confined tumor showed significantly more normal or normalizing CEA levels within 1-6 weeks (17/27), whereas patients with overt metastases developed more pathological or increasingly pathological levels (8/11).
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