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BCL6 coordinates muscle mass homeostasis with nutritional states.
Proc Natl Acad Sci U S A
January 2025
Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037-1002.
Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional status; however, the detailed mechanisms remain to be fully elucidated. Here, we show that the transcriptional repressor B cell lymphoma 6 (BCL6) maintains muscle mass by sustaining GH action.
View Article and Find Full Text PDFHallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan.
Front Aging
January 2025
Molecular Medicine, NSW Health Pathology, John Hunter Hospital, Newcastle, NSW, Australia.
Aging is a complex process marked by various changes at both cellular and systemic levels, impacting the functioning and lifespan of organisms. Over time, researchers have pinpointed several significant hallmarks of aging that lead to the gradual deterioration of tissue function, regulation, and homeostasis associated with aging in humans. Despite this, the intricate interactions and cumulative effects of these hallmarks are still mostly uncharted territory.
View Article and Find Full Text PDFIdentification of glutamine as a potential therapeutic target in dry eye disease.
Signal Transduct Target Ther
January 2025
Department of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Dry eye disease (DED) is a prevalent inflammatory condition significantly impacting quality of life, yet lacks effective pharmacological therapies. Herein, we proposed a novel approach to modulate the inflammation through metabolic remodeling, thus promoting dry eye recovery. Our study demonstrated that co-treatment with mesenchymal stem cells (MSCs) and thymosin beta-4 (Tβ4) yielded the best therapeutic outcome against dry eye, surpassing monotherapy outcomes.
View Article and Find Full Text PDFGnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147.
Bone Res
January 2025
Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, PR China.
Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in regulating bone homeostasis and maintaining bone mass. We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density (BMD) in mice primarily by enhancement of osteoclast activation in vivo and in vitro.
View Article and Find Full Text PDFGonadotropins, local factors and a variety of adipokines contribute to regulate swine granulosa cell function.
Domest Anim Endocrinol
January 2025
Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Via del Taglio 10, 43126, Parma, Italy.
This paper reviews the role of endocrine regulators in swine ovarian cell functions, highlighting the intricate hormonal interactions that drive reproductive and metabolic processes. The pig represents a valuable model for human biology due to physiological and anatomical similarities. Understanding the endocrine mechanisms in swine can provide insights about human reproductive health and metabolic disorders.
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