Spontaneous quadruplet pregnancies are exceptional. As compared with singleton pregnancies, quadruplets are associated with a higher incidence of preterm labor, first-trimester bleeding, toxemia, anemia, stillbirths and perinatal deaths. We report a 25-year-old, black woman with a spontaneous quadruplet pregnancy. The patient had had a previous twin pregnancy and was herself a twin. The patient's mother had a history of twin and triplet pregnancies. Following the diagnosis, the patient was hospitalized and given betamethasone weekly. At 33 weeks' gestation she had spontaneous rupture of the membranes and delivered by cesarean section. The quadruplets had good Apgar scores and were discharged 5-10 weeks later in good health.
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