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A retrospective cohort study of monthly rifampicin, ofloxacin and minocycline in the management of leprosy at the Hospital for Tropical Diseases, London, United Kingdom.
PLoS Negl Trop Dis
December 2024
Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Introduction: The World Health Organization (WHO) recommends rifampicin, dapsone and clofazimine multi-drug therapy (MDT) for the treatment of leprosy. Severe adverse effects include dapsone hypersensitivity syndrome, skin pigmentation, haemolytic anaemia, and hepatitis. At the Hospital for Tropical Diseases (HTD), London, United Kingdom monthly rifampicin, ofloxacin and minocycline (mROM) is used as first line treatment for leprosy.
View Article and Find Full Text PDFAntibiotic, hormonal/metabolic, and retinoid therapies for hidradenitis suppurativa.
J Am Acad Dermatol
December 2024
Department of Dermatology, Stanford University School of Medicine, Redwood City, California. Electronic address:
Background: Hidradenitis suppurativa (HS), a chronic painful inflammatory skin condition, remains a persistent challenge in dermatology. Its complex pathogenesis has yet to be fully understood, complicating the identification of effective therapeutic strategies.
Objective: This study aims to investigate the latest insights on antibiotics, hormonal/metabolic interventions, and oral retinoids in the management of HS.
The role of antibiotic-derived mycobacterial vesicles in tuberculosis pathogenesis.
Sci Rep
November 2024
Department of Microbiology, Immunology and Glycobiology, Institution of Laboratory Medicine, Lund University, Lund, Sweden.
Article Synopsis
- Pulmonary tuberculosis (TB) can lead to lasting damage in lung tissue, and mycobacterial vesicles (MVs) are being studied for their role in TB-related issues.
- Research showed that stress from TB antibiotics increased MV formation, with vesicles being around 40 nm and containing various lipids and different protein profiles based on the type of antibiotic used.
- While these MVs weren't toxic to human cells, they did provoke specific inflammatory responses, suggesting that they could be significant players in TB pathology.
Negative outcome in cutaneous Mycobacterium marinum infection treated with surgical intervention: Two-case report.
Medicine (Baltimore)
October 2024
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Rationale: Mycobacterium marinum (M marinum), a slow-growing nontuberculous mycobacterium (NTM), is widely distributed in aquatic environments. It is a well-known cutaneous pathogen, which causes sporotrichosis-like lesions.
Patient Concerns: In this report, we describe 2 cases of subcutaneous M marinum infection.
Two for One: Tuberculid and Leukocytoclastic Vasculitis in an Adolescent.
Pediatr Dermatol
September 2024
Division of Dermatology, Children's National Hospital, Washington, DC, USA.
Article Synopsis
- A 13-year-old girl experienced fevers, abdominal pain, and vomiting for 4 days, followed by a full body itchy rash after being treated for tuberculosis with RIPE therapy for 1 month.
- Skin biopsies revealed leukocytoclastic vasculitis and tuberculid pathologies, indicating she had a hypersensitivity reaction to tuberculosis.
- The case emphasizes the need for early histopathology to accurately diagnose rashes that may resemble other diseases.
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