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Nanocrystalline formulations typically contain stabilizing additives to minimize the risk of particle growth or agglomeration. This risk is particularly relevant when the nanosuspension is converted into a solid drug product as the original state of the nanosuspension should be restored upon redispersion of the drug product in vivo. In this work, the behavior of different nonionic and anionic surfactants in solid nanocrystalline formulations and their effects on redispersibility under biorelevant conditions were investigated.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Department of Separation Science, School of Engineering Science, Lappeenranta-Lahti University of Technology (LUT), Yliopistonkatu 34, 53850, Lappeenranta, Finland.
As the global consumption of pharmaceuticals increases, so does their release into water bodies. The effects, although not fully understood, can be detrimental to aquatic ecosystems and human health. The new Urban Wastewater Treatment Directive (UWWTD) in European Union requires implementation of quaternary wastewater treatment processes to limit the loads of pharmaceuticals reaching water bodies.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Sanitary Engineering Laboratory, Department of Water Resources and Environmental Engineering, School of Civil Engineering, National Technical University of Athens, 9 Iroon Polytechniou St., Zographou Campus, 15773, Athens, Greece.
Vertical subsurface flow constructed wetlands (VSSF CWs) were employed to investigate the use of biochar that could be produced with local agricultural biomass through pyrolysis, recycled glass from local recycling companies and gel beads with decreased packing volume and shipping cost as substrate alternatives to sand. The materials were assessed in terms of granulometry, porosity, adsorption capacity and hydraulic conductivity and were used for the treatment of an upflow anaerobic sludge blanket (UASB) reactor, treating domestic wastewater, effluent. Granulometry was a major factor impacting TSS removal that ranged from 81% ± 10% to 97% ± 2%.
View Article and Find Full Text PDFMethods Protoc
January 2025
Department of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
Multi-drug delivery systems have gained increasing interest from the pharmaceutical industry. Alongside this is the interest in amorphous solid dispersions as an approach to achieve effective oral delivery of compounds with solubility-limited bioavailability. Despite this, there is limited information regarding predicting the behavior of two or more drugs (in amorphous forms) in a polymeric carrier and whether molecular interactions between the compounds, between each compound, and if the polymer have any effect on the physical properties of the system.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
Department of Anatomy, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, China; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China. Electronic address:
Astragalin (AST), a natural flavonoid, exhibits anti-inflammatory, anti-cancer, and antioxidant properties. However, its effects and molecular mechanisms in inflammatory pain remain unclear. Therefore, this study aims to investigate the impact of AST on a Complete Freund's Adjuvant (CFA)-induced inflammatory pain mouse model and to elucidate its potential mechanisms.
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