Objective: To determine whether changes in peripheral beta-endorphin levels during the periovulatory phase are associated with symptoms of premenstrual syndrome (PMS).
Methods: Twenty-one PMS patients and ten controls were studied. All were in general good health and had no history of psychiatric disorders. They were between 21-44 years of age, had had regular menses for at least six previous cycles, and were carefully selected by charting the Visual Linear Analogue Scale and basal body temperature daily for 1 month. After an overnight fast, the subjects had blood drawn between 8:00 and 10:00 AM daily for 8 days, starting on the tenth day of the menstrual cycle, for one cycle. Beta-endorphin and LH were measured by radioimmunoassay. The day of the LH peak was defined as day LH 0. The beta-endorphin levels were expressed as the number of days before or after the LH surge.
Results: Beta-endorphin levels throughout the periovulatory phase were lower in PMS patients than in controls, and the differences were more remarkable on LH days 0 and 4.
Conclusion: Our data suggest that an aberration of normal changes in beta-endorphin activity in PMS patients may occur around the time of ovulation.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway.
Chin Med
December 2024
Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Huazhong University of Science and Technology, Wuhan, 430030, China.
Background: Chronic inflammatory pain is a pervasive condition, and electroacupuncture (EA) is an effective treatment, but its mechanisms are not fully understood. AMP-activated protein kinase (AMPK), a key energy sensor, is involved in pain relief and EA's effects. EA may work by increasing endocannabinoids, upregulating CB2 receptors (CB2R), and stimulating β-endorphin (β-END).
View Article and Find Full Text PDFPaternal morphine alters offspring circulating beta-endorphin and corticosterone responses to oxycodone and cocaine.
Neuropharmacology
March 2025
Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, USA. Electronic address:
Background: The opioid epidemic is leading to increased opioid use in adolescent populations. A growing body of evidence suggests that taking opioids during adolescence can disrupt normal development and impact future offspring. This study investigates the impact of paternal morphine exposure during adolescence on the hypothalamic-pituitary-adrenal (HPA) axis and release of endorphins in the offspring.
View Article and Find Full Text PDFEffects of wet cupping in a rat model of primary dysmenorrhea.
J Ayurveda Integr Med
December 2024
Faculty Health of Science, Muhammadiyah University of Jember, Jember, East Java, Indonesia.
Background: Primary dysmenorrhea (PD) is characterized by discomfort with no organic etiology (no pelvic disease), recurring pain, or lower abdominal cramps that start between the first 8-72 h of menstruation. Cupping therapy uses a tool to form a vacuum at certain points on the skin.
Objectives: We investigated the mechanism of pain relief caused by cupping therapy in primary dysmenorrhea that is played by cupping therapy in PD.
Perioperative Pain Observation of Hip Fracture Surgery Patients with Cheek Acupuncture.
J Pain Res
November 2024
Department of Anesthesiology, Lu'an Hospital of Anhui Medical University, Luan, 237000, People's Republic of China.
Background: The objective of this study is to investigate the impact of cheek acupuncture on perioperative pain in patients with hip fracture.
Methods: A random number table was utilized to allocate the patients into three distinct cohorts: Only spinal anesthesia was performed (group S), cheek acupuncture was performed before spinal anesthesia (group C), and ultrasound-guided fascia iliaca block was performed before spinal anesthesia (group F). The primary outcome measure was the Visual Analogue Scale (VAS) score within 24 hours post-surgery, as well as the level of beta-endorphin.
Effect of Laparoscopic Inguinal Hernia Repairs on Inflammatory Factors, Oxidative Stress Levels and Postoperative Recovery.
J Inflamm Res
October 2024
Department of Hernia and Abdominal Wall Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030032, People's Republic of China.
Objective: To unravel the effects of different laparoscopic inguinal hernia repairs (IHRs) on inflammatory factors, oxidative stress, and postoperative recovery of inguinal hernia (IH) patients.
Methods: A total of 88 patients for laparoscopic treatment of IH were studied in a retrospective cohort, and were randomized into the transabdominal preperitoneal (TAPP) repair group (n = 44) and the total extraperitoneal (TEP) repair group (n = 44) according to the method of treatment. Patients in the TAPP group underwent laparoscopic TAPP IHR, while patients in the TEP group underwent laparoscopic TEP IHR.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!