Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1212/wnl.44.4.779 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Early identification of Alzheimer's disease (AD) risk prior to irreversible brain damage is critical for improving the success of interventions and treatment. Cortical thickness is a macrostructural measure typically used to assess AD neurodegeneration. However, cortical microstructural changes appear to precede macrostructural atrophy and may improve early identification of AD risk.
View Article and Find Full Text PDFBackground: Cholinergic innervation is particularly vulnerable in many neurodegenerative diseases such as Alzheimer's diseases. Nerve growth factor (NGF) plays a major role in the maintenance and function of cholinergic neurons, and a decrease in trophic signalling by NGF-Tropomyosin receptor kinase A (TrkA) contributes to cholinergic and synaptic degeneration. E2511 is a novel small molecule TrkA biased positive allosteric modulator showing an increase in specific trophic signalling via direct binding to TrkA with a potential to recover and reinnervate damaged cholinergic neurons.
View Article and Find Full Text PDFBackground: Early alterations in the ventral tegmental area, a major brainstem dopaminergic nucleus, may be a marker of Alzheimer' disease (AD). However, how dopamine (DA) may influence neurofunctional and cognitive decline due to AD remains elusive. The aim of this study was to investigate alterations in resting-state functional connectivity (FC) associated with DA distribution in the brain along the AD continuum.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Deficits in interneuron and cholinergic circuits are noted in AD pathology, yet the precise mechanisms of their contribution to cognitive decline in the disease remain elusive. Neuronal Pentraxin 2 (NPTX2), a sensitive marker for synaptic activity and AD progression, is an immediate early gene expressed by pyramidal neurons that functions at excitatory synapses on Parvalbumin interneurons (PV-IN) to cluster AMPA receptors and strengthen circuit inhibition. NPTX2 is later shed from some synapses into the cerebrospinal fluid (CSF), where reduced NPTX2 levels inversely correlate with hippocampal volume and cognitive performance in individuals with AD/MCI.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
University of California, San Diego, La Jolla, CA, USA.
Background: Early identification of Alzheimer's disease (AD) risk prior to irreversible brain damage is critical for improving the success of interventions and treatment. Cortical thickness is a macrostructural measure typically used to assess AD neurodegeneration. However, cortical microstructural changes appear to precede macrostructural atrophy and may improve early identification of AD risk.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!