Autonomic and peptidergic innervation of the human larynx (vocal cords, ventricular folds, epiglottis, subglottic region and recurrent nerves) was studied by application of single and double immunocytochemistry and radioimmunoassay. In all tissues investigated, immunoreactivities for a variety of regulatory peptides were detected and included vasoactive intestinal polypeptide (VIP), peptide histidine methionine (PHM), helospectin, neuropeptide Y (NPY), C-flanking peptide of NPY (C-PON), calcitonin gene-related peptide (CGRP), substance P and neurokinin A. In the recurrent nerves, only a few peptide-immunoreactive nerve fibers were found. The laryngeal region of the epiglottis and the subglottic region showed characteristic corpuscular nerves containing substance P and CGRP running underneath and within the epithelium.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation.
Front Mol Neurosci
December 2024
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States.
Introduction: The prostate is densely innervated like many visceral organs and glands. However, studies to date have focused on sympathetic and parasympathetic nerves and little attention has been given to the presence or function of sensory nerves in the prostate. Recent studies have highlighted a role for sensory nerves beyond perception of noxious stimuli, as anterograde release of neuropeptides from sensory nerves can affect vascular tone and local immune responses.
View Article and Find Full Text PDFPeripheral and central innervation pattern of mechanosensory neurons in the trigeminal ganglion.
Neuroscience
January 2025
Institute of Neuroscience, Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:
The trigeminal ganglion (TG) comprises primary sensory neurons responsible for orofacial sensations, subsequently projecting to the trigeminal nuclei in the brainstem. However, the circuit basis of nasal mechanosensation is not well characterized. Here we elucidate the anatomical organization of both peripheral and central projections of the TG.
View Article and Find Full Text PDFGenetic tools that target mechanoreceptors produce reliable labeling of bladder afferents and altered mechanosensation.
Am J Physiol Renal Physiol
November 2024
Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, WI, USA.
Article Synopsis
- Mechanosensitive neurons play a crucial role in sensing bladder stretching, but their involvement in urologic diseases is not well understood, especially regarding CGRP-negative mechanoreceptors.
- A study found a significant number of bladder nerve fibers that are NFH-positive but CGRP-negative, indicating potential unexplored mechanoreceptors.
- By using genetic strategies to label these mechanoreceptors, researchers demonstrated that TrkB neurons are essential for bladder mechanosensation, as the absence of these neurons increased the pressure required for voiding and led to non-voiding contractions after bladder distention.
Pharmacological differences in postoperative cutaneous sensitivity, pain at rest, and movement-induced pain in laparotomized mice.
Biomed Pharmacother
November 2024
Department of Pharmacology, Faculty of Medicine, University of Granada, Granada 18016, Spain; Institute of Neuroscience, Biomedical Research Center, University of Granada, Armilla, Granada 18100, Spain; Biosanitary Research Institute ibs.GRANADA, Granada 18012, Spain; Teófilo Hernando Institute for Drug Discovery, Madrid 28029, Spain. Electronic address:
Postoperative pain management is challenging. We used mice with a transverse laparotomy to study tactile allodynia measured by the von Frey test, pain at rest measured by facial pain expressions detected by an artificial intelligence algorithm, and movement-induced pain measured by reductions in exploratory activity. The standard analgesics morphine and ibuprofen induced distinct patterns of outcome-dependent effects.
View Article and Find Full Text PDFImpaired Tertiary Dentin Secretion after Shallow Injury in -Deficient Dental Pulp Cells Is Rescued by Extended CGRP Signaling.
Int J Mol Sci
June 2024
Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH 43210, USA.
The transforming growth factor β (TGFβ) superfamily is a master regulator of development, adult homeostasis, and wound repair. Dysregulated TGFβ signaling can lead to cancer, fibrosis, and musculoskeletal malformations. We previously demonstrated that TGFβ receptor 2 () signaling regulates odontoblast differentiation, dentin mineralization, root elongation, and sensory innervation during tooth development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!