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Relationship between the AGT M235T genetic variant and the characteristics and prognosis of coronary atherosclerosis in patients with acute myocardial infarction.
Mol Biol Rep
October 2024
Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang, District 5, Ho Chi Minh City, 700000, Vietnam.
Article Synopsis
- Genetic factors, notably the AGT M235T variant, were studied in relation to acute myocardial infarction (AMI) among 504 Vietnamese patients, aiming to analyze their impact on coronary atherosclerosis and 12-month mortality rates.
- The study found that the majority of patients had the TT genotype, and there were no significant differences in coronary artery conditions or mortality between different genotype groups.
- The conclusion indicated that the AGT M235T variant showed no association with atherosclerosis or mortality within the 12-month follow-up, suggesting a need for larger studies to confirm these findings.
ATR1 A1166C (rs5186), FII G20210A (rs1799963), FV G1691A (rs6025), FXIII 97G > T (rs11466016) and MTHFR A1298C (rs1801131) polymorphisms and the risk of ST-elevation myocardial infarction in young Mexican individuals.
Mol Biol Rep
January 2024
Medical Research Unit in Reproductive Medicine, Mexican Social Security Institute, Highly Specialized Medical Unit No. 4, Mexico City, Mexico.
Article Synopsis
- A study investigated the link between specific genetic polymorphisms and ST elevation Myocardial Infarction in young Mexican individuals, involving 350 patients under 45 and 350 matched controls.
- The A1166C polymorphism was found to significantly increase the risk of Myocardial Infarction, while G20210A, G1691A, 97G > T, and A1298C did not show a similar association.
- Other factors like dyslipidemia, hypertension, smoking, and family history were also linked to increased risks, indicating that genetic variations might contribute to early cardiovascular issues, but more research is needed on gene interactions.
Association of the ACE and AGT gene polymorphisms with global disparities in COVID-19-related deaths.
Pharmacogenet Genomics
April 2023
Natural Sciences Department, School of Arts and Sciences, Lebanese American University, Lebanon.
Objective: The aim of the study was to investigate the gene polymorphisms of angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin type 1 receptor (AT1R) in association with coronavirus disease 2019 (COVID-19) mortality rates worldwide.
Methods: The prevalence of ACE I/D, AGT M235T, and AT1R A1166C alleles' frequencies in different populations was assessed. Data on COVID-19-related cases and deaths were acquired from the European Center for Disease Prevention and Control, which included weekly reports by country and continent.
Polymorphisms in the Renin-Angiotensin System and eNOS Glu298Asp Genes Are Associated with Increased Risk for Essential Hypertension in a Mexican Population.
J Renin Angiotensin Aldosterone Syst
March 2023
Medical Research Unit in Reproductive Medicine, Highly Specialized Medical Unit No. 4, Mexican Social Security Institute, Mexico City, Mexico.
Background: Essential hypertension is the result of modifiable and genetic factors, and it is associated with increased risk for atherothrombosis. Some polymorphisms are associated with hypertensive disease. The objective was to analyze the association between eNOS Glu298Asp, MTHR C677T, AGT M235T, AGT T174M, and A1166C and ACE I/D polymorphisms with essential hypertension in the Mexican population.
View Article and Find Full Text PDFGenetic Polymorphism in Angiotensinogen and Its Association with Cardiometabolic Diseases.
Metabolites
December 2022
Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha 61514, Saudi Arabia.
Angiotensinogen (AGT) is one of the most significant enzymes of the renin-angiotensin-aldosterone system (RAAS) which is involved in the regulation and maintenance of blood pressure. AGT is involved in the production of angiotensin I which is then converted into angiotensin II that leads to renal homeostasis. However, various genetic polymorphisms in AGT have been discovered in recent times which have shown an association with various diseases.
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