Eleven patients (nine women) with persistent faecal incontinence after rectopexy for rectal prolapse were treated by postanal repair. Follow-up data, including clinical and anorectal physiology, at 5-8 years (median 76 (range 64-95) months) were available for nine patients. At long-term follow-up, seven of the nine patients had improved continence (two were continent to solid and liquid stools, and five to solid stool). One patient required a colostomy. Median (range) physiological findings before and after postanal repair in the nine patients were: anal canal length 2.3 (1.5-3.0) versus 3.5 (2.0-5.5) cm (P < 0.05); resting anal pressure 20 (0-49) versus 35 (10-55) cmH2O (P < 0.05); perineal descent 2 (1-3) versus 0 (3 to -0.2) cm; and mean pudendal nerve terminal motor latency 2.35 (2.0-3.1) versus 2.85 (2.3-3.4) ms.
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http://dx.doi.org/10.1002/bjs.1800810254 | DOI Listing |
bioRxiv
October 2024
Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA.
The neonatal mouse cerebellum shows remarkable regenerative potential upon injury at birth, wherein a subset of Nestin-expressing progenitors (NEPs) undergoes adaptive reprogramming to replenish granule cell progenitors that die. Here, we investigate how the microenvironment of the injured cerebellum changes upon injury and contributes to the regenerative potential of normally gliogenic-NEPs and their adaptive reprogramming. Single cell transcriptomic and bulk chromatin accessibility analyses of the NEPs from injured neonatal cerebella compared to controls show a temporary increase in cellular processes involved in responding to reactive oxygen species (ROS), a known damage-associated molecular pattern.
View Article and Find Full Text PDFAnal fistula is a rapidly developing anorectal disease that can lead to anal dysfunction if left untreated. Minimally invasive surgery is an important treatment option for anal fistula, as it can reduce the risk of anal sphincter injury and protect anal function. However, postoperative complications such as infection, pain, bleeding, edema, and fat liquefaction can occur, resulting in slow wound healing thus negatively impacting the patient's quality of life.
View Article and Find Full Text PDFDis Colon Rectum
September 2024
Department of Nursing, Mayo Clinic, Rochester, Minnesota.
Background: There has been a shift in the treatment of fistula-in-ano towards a focus on preservation of continence while simultaneously eradicating disease. Utilization of radially emitting diode laser catheters to ablate fistula tracks has been described since 2011 with heterogenous studies publishing success rates ranging from 20% to 89%.
Objective: Present our experience managing solitary transsphincteric fistulas of cryptoglandular origin with radially emitting diode laser.
Exp Anim
May 2021
Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, Hubei Province, P.R. China.
Both cholinergic and adrenergic stimulation can induce sweat secretion in human eccrine sweat glands, but whether cholinergic and adrenergic stimulation play same roles in rat eccrine sweat glands is still controversial. To explore the innervations, and adrenergic- and cholinergic-induced secretory response in developing and developed rat eccrine sweat glands, rat hind footpads from embryonic day (E) 15.5-20.
View Article and Find Full Text PDFSurg Res Pract
January 2016
Department of Colorectal Surgery, Division of General and Gastrointestinal Surgery, Donostia University Hospital, 20014 San Sebastián, Spain.
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