AI Article Synopsis
- Studied four generations of a family from the Canary Islands with a hereditary hearing loss and IgA mesangial glomerulonephritis, likely passed down in an autosomal dominant manner.
- Explored different hereditary syndromes, including Alport's syndrome and other autosomal transmission hearing losses, noting key differences in their clinical presentations.
- Highlighted the potential autoimmune link due to the presence of IgA nephropathy in the family, detailing characteristics of the syndrome under investigation.
Article Abstract
We studied four generations of a Canary Islands family presenting a tardive heredodegenerative hearing loss, associated with IgA mesangial glomerulonephritis, of probable autosomal dominant heredity. With respect to the family, we revised Alport's syndrome, for possible transmission associated with X chromosome, as well as heredodegenerative hearing loss associated with renal pathology of autosomic transmission currently described; we differentiate these hearing losses from our case study, and we discuss the pathogeny of the auditive affection in the said hereditary syndromes. Lastly, we stress the autoimmune hypothesis because of the IgA nephropathy association in the family case, and we list the characteristics of the syndrome described.
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