The Burke and Wills expedition through the interior of Australia in the nineteenth century ended in calamity. But the cause of death was more pernicious than anyone at the time had imagined: beriberi due to thiaminase poisoning.
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A Mysterious Cause of Coagulopathy With Bleeding Diathesis.
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Department of Internal Medicine IV, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.
Vitamin K is essential to produce functional vitamin K-dependent coagulation factors (prothrombin, factors VII, IX, and X). Vitamin K antagonists inhibit the normal activation of these factors, leading to bleeding manifestations of variable severity. Long-acting vitamin K antagonists or superwarfarins were developed as rodenticides and have a significantly longer half-life and greater potency when compared to warfarin.
View Article and Find Full Text PDFMysterious Allergy Caused by Tick Bite: Alpha-Gal Syndrome.
Turkiye Parazitol Derg
October 2024
Ege University, Graduate School of Natural and Applied Sciences, Department of Biology, İzmir, Türkiye.
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Yes-associated protein inhibition ameliorates carbon tetrachloride-induced acute liver injury in mice by reducing VDR.
Chem Biol Interact
August 2024
Deparment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, 215123, China. Electronic address:
Carbon tetrachloride (CCl) has a wide range of toxic effects, especially causing acute liver injury (ALI), in which rapid compensation for hepatocyte loss ensures liver survival, but proliferation of surviving hepatocytes (known as endoreplication) may imply impaired residual function. Yes-associated protein (YAP) drives hepatocytes to undergo endoreplication and ploidy, the underlying mechanisms of which remain a mystery. In the present study, we uncover during CCl-mediated ALI accompanied by increased hepatocytes proliferation and YAP activation.
View Article and Find Full Text PDFMethanol Induced Optic Neuropathy: Molecular Mysteries, Public Health Perspective, Clinical Insights and Treatment Strategies.
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Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.
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The Perception and Treatment of People about Abscesses in the Song Period: Focus on Hongmai Yijianzhi.
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April 2024
Associate Professor, Department of History, Ewha Womans University.
During the Song period, abscesses were a disease that could affect anyone regardless of their class. This study examines how people at that time explained the cause of abscesses and their efforts to treat them, focusing on the experiences of those who suffered from abscesses and their families. Previous research on disease history during the Song period primarily focused on ailments like colds and infectious diseases , or plagues prevalent in the southern regions of China.
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