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Alzheimers Dement
December 2024
Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute, Barcelona, Spain.
Background: Lifestyle interventions targeting multiple Alzheimer's disease (AD) risk factors are effective strategies to prevent cognitive decline. Emerging evidence suggests synergistic effects between various intervention components, including lifestyle modifications, supplements, and pharmacological approaches. The PENSA study, part of the World-Wide FINGERs network, is a randomized, double-blind clinical trial following the Finger 2.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Gastroenterology of Shenzhen Second People's Hospital, Health Science Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People's Republic of China.
Previous studies on the correlation between serum selenium and hypertension have yielded inconsistent results. Our previous analysis of participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 indicated that elevated serum selenium concentrations were associated with an increased risk of metabolic abnormalities in obese individuals, with the primary effect being on blood pressure in males. The aim of this study was to further elucidate the relationship between serum selenium and the risk of hypertension in obese males.
View Article and Find Full Text PDFNPJ Aging
January 2025
Department of Molecular Genetics, Kumamoto University, Kumamoto, Japan.
Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergothioneine (EGT), an antioxidant with potential health benefits. In this study, we assessed the possibility that long-term consumption of Tamogi-take mushrooms might attenuate age-related decline in cardiac and vascular endothelial function in mice.
View Article and Find Full Text PDFJ Med Food
January 2025
Laboratory of Applied Microbiology, Faculty of Sciences of Nature and Life, University Ferhat Abbes Sétif 1, Sétif, Algeria.
L., or "Sedra" in North Africa, is a wild jujube from the Rhamnaceae family. Its fruit, "Nbeg," is used in traditional medicine to treat various ailments, such as tuberculosis, bronchitis, liver disorders, and gastrointestinal issues.
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January 2025
Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, 12622, Egypt.
It is crucial to develop new tactics to prevent ovarian tissue damage in women whose reproductive toxicity is caused by chemotherapy. The present investigation was performed to assess the protective effects of Moringa oleifera (M. oleifera) leaf extract on cyclophosphamide (CP)-induced ovarian damage and reproductive dysfunction.
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