Assays of glucose and proteic sulphur levels in the hair of patients with recently detected IDDM provided information on the preclinical stage of insulin secretion disorders, which was estimated at 6 +/- 2 months. Such investigations in subjects at high risk of developing an IDDM might reveal the period preceding the disease onset, thus enabling to start an early therapy.
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Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
To the best of our knowledge, no studies in the literature have reported on the relationship between the pregnancy-associated glycoprotein (PAG) concentration and undernutrition during pregnancy in sheep. Therefore, the aim of this study was to investigate the effects of undernutrition on the blood concentration of PAGs in pregnant ewes carrying single and multiple fetuses, undergoing either dietary energy restriction or receiving 100% of their energy requirements during the period of maximal placenta growth. From d 24 to 100 of pregnancy, the ewes were fed ryegrass hay and two different iso-proteic concentrates, fulfilling either 100% of the ewes' energy requirements (control group; n = 30, 14 singleton pregnancies, 16 multiple pregnancies) or only 50% (feed-restricted group; n = 29; 11 singleton pregnancies, 18 multiple pregnancies).
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Department of Drug Science, Section of Biochemistry, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Pathophysiological mechanisms correlating diabetes mellitus with associated complications are still not completely clear, even though oxidative stress seems to play a pivotal role. Literature data suggest that cell damages induced by hyperglycemia, although multifactorial, have a common pathway in oxidative/nitrosative stress. The present study evaluated the effects of Raf.
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Laboratoire de Productions Animales et Fourragères, INRA-Tunisia, University of Carthage, Rue Hédi Karray, 2049 Ariana, Tunisia.
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1Department of Neuroscience, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. 2Department of Environmental Health Sciences, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. 3Centro di Ricerca E. Menni, Fondazione Poliambulanza-Istituto Ospedaliero, Brescia, Italy. 4Department of Cerebrovascular Diseases, Fondazione IRCCS-Istituto Neurologico Carlo Besta, Milan, Italy. 5Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. 6Department of Biochemistry, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
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