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KDM6A facilitates Xist upregulation at the onset of X inactivation.
Biol Sex Differ
January 2025
Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, 98195, USA.
Background: X chromosome inactivation (XCI) is a female-specific process in which one X chromosome is silenced to balance X-linked gene expression between the sexes. XCI is initiated in early development by upregulation of the lncRNA Xist on the future inactive X (Xi). A subset of X-linked genes escape silencing and thus have higher expression in females, suggesting female-specific functions.
View Article and Find Full Text PDFDifferent thermal regimes and susceptibility to herbivory do not constrain seagrass seedling restoration.
Mar Environ Res
December 2024
University of Sassari, Department of Chemical, Physical, Mathematical and Natural Sciences, Sassari, Italy; National Biodiversity Future Centre, Palermo, Italy.
Recovering seagrass ecosystems through restoration has become impellent to re-establish their functionality and services. Although the use of seedlings may represent an appropriate solution, little information is provided on the seedling-based restoration effectiveness with influence of biotic and abiotic interactions. Survival, morphological development and leaf total phenol content of transplanted Posidonia oceanica seedlings were evaluated under different origin, thermal regimes and herbivore pressure through a five-months field experiment in two MPAs, located on the west (cold) and east (warm) Sardinia coast to explore the effectiveness of seedling-based restoration.
View Article and Find Full Text PDFTuning Optical and Electrical Properties of Vanadium Oxide with Topochemical Reduction and Substitutional Tin.
Chem Mater
November 2024
National Renewable Energy Laboratory, Golden, Colorado 80401, United States.
Vanadium oxides are widely tunable materials, with many thermodynamically stable phases suitable for applications spanning catalysis to neuromorphic computing. The stability of vanadium in a range of oxidation states enables mixed-valence polymorphs of kinetically accessible metastable materials. Low-temperature synthetic routes to, and the properties of, these metastable materials are poorly understood and may unlock new optoelectronic and magnetic functionalities for expanded applications.
View Article and Find Full Text PDFResponse of the nephron arterial network and its interactions to acute hypertension: a simulation.
Function (Oxf)
November 2024
University of Copenhagen, Department of Biomedical Sciences, Panum Institute Copenhagen, Denmark.
We simulated the dynamics of a group of 10 nephrons supplied from an arterial network and subjected to acute increases in blood pressure. Arterial lengths and topology were based on measurements of a vascular cast. The model builds on a previous version exercised at a single blood pressure with 2 additional features: pressure diuresis and the effect of blood pressure on efferent arteriolar vascular resistance.
View Article and Find Full Text PDFReal-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a two-year follow-up of the prospective clinical trial COVAXID.
EBioMedicine
November 2024
Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:
Article Synopsis
- Immunocompromised patients have shown weak responses to initial SARS-CoV-2 mRNA vaccinations, prompting recommendations for extra booster doses; however, real-world data on these recommendations is limited.
- A two-year follow-up of the COVAXID clinical trial involved 364 participants, focusing on their immune responses and the effects of their vaccination schedule and underlying health conditions.
- The study found that while some patients who initially had poor responses improved after additional doses, their immune response remained affected by their immunosuppressive status, emphasizing the need for ongoing vaccination efforts in these populations.
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