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"Combined synergistic effects of concentrated growth factors and adipose-derived mesenchymal stem cells on regeneration of induced mandibular defects in rabbits".
Cytotherapy
December 2024
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Hebei Technology Innovation Center of Oral Health, Hebei Medical University & Hebei Key Laboratory of Stomatology & Hebei Clinical Research Center for Oral Diseases, Shijiazhuang, 050017, China. Electronic address:
Objective: This study aimed to evaluate the potential of combining allogeneic adipose-derived mesenchymal stem cells (ADSCs) with autologous concentrated growth factors (CGF) to enhance the repair of mandibular defects in rabbits.
Methods: Rabbit ADSCs were characterized using flow cytometry, identifying CD73, CD90, and CD105 as surface markers, while Alizarin Red Staining confirmed osteogenic differentiation, showing substantial mineralized deposits by day 21. A total of 24 New Zealand white rabbits were divided into four groups: BLANK (control group), CGF, ADSCs, and ADSCs/CGF.
Low Bone Turnover, Mineralization Impairment, and Cortical Alterations in Patients with Axial Spondyloarthritis: A Histomorphometric Study.
Calcif Tissue Int
January 2025
Internal Medicine Division, Federal University of Parana (UFPR), Curitiba, PR, Brazil.
Patients with radiographic axial spondyloarthritis (r-axSpA) experience a higher prevalence of fragility fractures, though the pathophysiology of osteoporosis associated with this disease remains poorly understood. The objective of this study was to evaluate the histomorphometric data in r-axSpA patients. Male r-axSpA patients up to 55 years old were enrolled in this cross-sectional study.
View Article and Find Full Text PDF[Identification of osteoid and chondroid matrix mineralization in primary bone tumors using a deep learning fusion model based on CT and clinical features: a multi-center retrospective study].
Nan Fang Yi Ke Da Xue Xue Bao
December 2024
Department of Radiology, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics of Guangdong Province), Guangzhou 510630, China.
Methods: We retrospectively collected CT scan data from 276 patients with pathologically confirmed primary bone tumors from 4 medical centers in Guangdong Province between January, 2010 and August, 2021. A convolutional neural network (CNN) was employed as the deep learning architecture. The optimal baseline deep learning model (R-Net) was determined through transfer learning, and an optimized model (S-Net) was obtained through algorithmic improvements.
View Article and Find Full Text PDFRepair of Osteoporotic Bone Defects in Rats via the Sirtuin 1-Wnt/β-catenin Signaling Pathway by Novel Icariin/Porous Magnesium Alloy Scaffolds.
Biomater Res
December 2024
Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, 518036 Shenzhen, Guangdong, China.
Article Synopsis
- * Sprague-Dawley rats underwent a surgical procedure to create bone defects, after which the new scaffold was implanted and assessed for biocompatibility and effectiveness over 8 and 12 weeks.
- * Results showed that the ICA/porous magnesium alloy scaffold enhanced bone regeneration and expression of important proteins related to bone health, with the SIRT1-Wnt/β-catenin signaling pathway likely playing a key role in this process.
Optimized Methyl methacrylate embedding of small and large undecalcified bones.
MethodsX
December 2024
Yale School of Medicine, Department of Orthopaedics and Rehabilitation, PO Box 208071, New Haven, CT 06510, USA.
Article Synopsis
- * The updated protocols improve upon past methods by using stabilized acrylamides for embedding and include guidelines for handling different sizes of histological samples, from small to large specimens like human bones.
- * The technique also enhances the clearing and infiltration processes, ensuring high-quality sample preparation verified through histological staining that maintains cellular detail, mineralization data, and enzymatic activity.
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