Globule leukocyte tumor involving the distal portion of the jejunum and proximal portion of the ileum caused chronic vomiting and weight loss in a 3-year-old cat. The intestinal mass was resected during exploratory laparotomy. The histologic appearance of the mass was characterized by inclusion of numerous intracytoplasmic eosinophilic granules. Similar cells were found in the mesenteric lymph node and were suggestive of metastasis. Tumor recurrence was not detected until 13.5 months after the surgery. The malignant but slow-growing nature of this tumor allowed a disease-free interval that exceeded 1 year, despite incomplete tumor resection.
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Newborn (Clarksville)
March 2024
Global Newborn Society, Clarksville Maryland, United States of America.
Food Funct
November 2024
Food College, Northeast Agricultural University, Harbin 150030, China.
Front Immunol
July 2024
Univ Paris Est Creteil, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mondor de la Recherche Biomédicale (IMRB), Creteil, France.
Introduction: CD39 plays an important role in the immunoregulation and inhibition of effector cells. It is expressed on immune cells, including Tregs, and on extracellular vesicles (EVs) budding from the plasma membrane. Platelet transfusion may induce alloimmunization against HLA-I antigens, leading to refractoriness to platelet transfusion with severe consequences for patients.
View Article and Find Full Text PDFMolecules
June 2024
Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, Nakamachi 2-24-16, Tokyo 184-8588, Japan.
The Omicron BA.5 variant of SARS-CoV-2 is known for its high transmissibility and its capacity to evade immunity provided by vaccine protection against the (original) Wuhan strain. In our prior research, we successfully produced the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein in an expression system.
View Article and Find Full Text PDFFood Chem
October 2024
Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address:
This study aimed to clarify the composition and bioactivity differences between goat and cow milk fat globule membrane (MFGM) protein by proteomic, and the immunomodulatory activity of MFGM proteins was further evaluated by using mouse splenic lymphocytes in vitro. A total of 257 MFGM proteins showed significant differences between goat and cow milk. The upregulated and unique MFGM proteins in goat milk were significantly enriched in the positive regulation of immune response, negative regulation of Interleukin-5 (IL-5) secretion, and involved in nucleotide-binding oligomerization domain (NOD)-like receptor signaling.
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