AI Article Synopsis
- A study investigated 43 squamous cell carcinomas in the head and neck by labeling them with iododeoxyuridine and analyzing through flow cytometry (FCM) and immunohistochemistry (IHC).
- The analysis successfully assessed 31 tumors, revealing a median labeling index (LI) of 13.6% from FCM and 9.1% from IHC, with notable differences between aneuploid and diploid cases.
- The findings suggested that the tumor doubling time (Tpot) calculated from IHC LI could serve as a prognostic factor, unlike Tpot derived from FCM LI.
Article Abstract
Forty-three squamous cell carcinomas of the head and neck region were in vivo labelled with the thymidine analogue iododeoxyuridine. Combined flow cytometric (FCM) and immunohistochemical (IHC) analysis was performed, and the following parameters calculated: labelling index (LI), S-phase time (TS) and potential tumor doubling time (Tpot). Complete FCM and IHC analyses could successfully be performed in 31 cases, showing a median LI of 13.6% with FCM and 9.1% with IHC. A correlation achieved between LI/FCM and LI/IHC was due to the aneuploid cases, whereas the diploid cases showed no such correlation. Data indicated that Tpot calculated with LI from IHC (Tpot/IHC) might be a prognostic factor, in contrast to Tpot determined using LI/FCM.
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| http://dx.doi.org/10.3109/02841869409098370 | DOI Listing |
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