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Comprehensive diagnosis in chronic coronary syndromes combining angiography and intracoronary testing: the AID-ANGIO study.
EuroIntervention
January 2025
Department of Cardiology, Hospital Clínico San Carlos IDISSC, CIBER-CV, Madrid, Spain and Universidad Complutense de Madrid, Madrid, Spain.
Background: The diagnostic yield of invasive coronary angiography (ICA) in patients with chronic coronary syndromes (CCS) in contemporary practice is uncertain.
Aims: We investigated the value of an advanced invasive diagnosis (AID) strategy combining angiography and intracoronary testing.
Methods: AID-ANGIO is an all-comers, prospective, multicentre study enrolling CCS patients referred for ICA.
Imaging human coronary cholesterol/urate crystals with cross-polarized micro-optical coherence tomography.
Front Cardiovasc Med
October 2024
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, United States.
Introduction: Birefringent crystals such as monosodium-urate (MSU) and cholesterol crystals (CC) likely contribute to the progression of coronary artery disease (CAD) due to their potential to exacerbate inflammation through inflammatory cytokine activation. Here, we present cross-polarized micro-optical coherence tomography (CP-µOCT) for visualizing individual birefringent crystals in human coronary arteries.
Methods And Results: Human cadaver coronary arteries with a history of CAD with or without gout were dissected for CP-µOCT imaging.
MI and Non-obstructive Coronary Arteries.
US Cardiol
July 2024
Division of Cardiology, Emory University School of Medicine Atlanta, GA.
Article Synopsis
- * Diagnostic methods for MINOCA include invasive imaging techniques and cardiac MRI, and conditions like myocarditis and takotsubo syndrome may be mistaken for it.
- * Although long-term treatment for MINOCA isn't standardized, medications such as ACE inhibitors and statins show promise in managing affected patients.
Emerging Hybrid Intracoronary Imaging Technologies and Their Applications in Clinical Practice and Research.
JACC Cardiovasc Interv
September 2024
Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom; Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom; Institute of Cardiovascular Sciences, University College London, London, United Kingdom. Electronic address:
Intravascular ultrasound and optical coherence tomography are used with increasing frequency for the care of coronary patients and in research studies. These imaging tools can identify culprit lesions in acute coronary syndromes, assess coronary stenosis severity, guide percutaneous coronary intervention (PCI), and detect vulnerable plaques and patients. However, they have significant limitations that have stimulated the development of multimodality intracoronary imaging catheters, which provide improvements in assessing vessel wall pathology and guiding PCI.
View Article and Find Full Text PDFIntracoronary ECG ST-segment shift remission time during reactive myocardial hyperemia: a new method to assess hemodynamic coronary stenosis severity.
Am J Physiol Heart Circ Physiol
October 2024
Department of Cardiology, University Hospital Bern (Inselspital), University of Bern, Bern, Switzerland.
Fractional flow reserve (FFR) measurements are recommended for assessing hemodynamic coronary stenosis severity. Intracoronary ECG (icECG) is easily obtainable and highly sensitive in detecting myocardial ischemia due to its close vicinity to the myocardium. We hypothesized that the remission time of myocardial ischemia on icECG after a controlled coronary occlusion accurately detects hemodynamically relevant coronary stenosis.
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