The frequency of spontaneous mutations affecting viability was estimated in the chromosome II in LA strain of Drosophila melanogaster. The strain has been selected for low sexual activity for more than 180 generations and maintained by close inbreeding. Spontaneous mutation rate in LA strain has appeared to be extremely high--the frequency of lethal and semilethal mutations in the chromosome II in by an order higher than usual mutation frequencies. Most of the mutations originating are distributed between a limited number of loci in the b--c region.
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