Background And Purpose: The purpose of this study was to evaluate the reliability of measurements of weight distribution among the wheels of wheelchairs using a commercial balance testing system. Reliable data may be useful in the wheelchair evaluation and adjustment process.
Subjects: Three male full-time manual wheelchair users aged 30, 26, and 27 years with cervical spinal cord injuries 7.5, 6.5, and 10 years in duration participated.
Methods: Calibration weights, unoccupied wheelchairs, and occupied wheelchairs were repeatedly placed on the force transducers of the balance testing system to obtain measurements of weight distribution.
Results: The intraclass correlation coefficients of the measurements were .99 for calibration weights, .96 for unoccupied wheelchairs and .98 for wheelchairs occupied by the subjects.
Conclusion And Discussion: The described use of this instrumentation appears to generate reliable measurements of static weight distribution. With further testing, this system may provide useful information related to manual wheelchair prescription and adjustment.
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http://dx.doi.org/10.1093/ptj/74.4.349 | DOI Listing |
BMC Bioinformatics
January 2025
Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Single-cell RNA sequencing (scRNA-seq) has transformed biological research by offering new insights into cellular heterogeneity, developmental processes, and disease mechanisms. As scRNA-seq technology advances, its role in modern biology has become increasingly vital. This study explores the application of deep learning to single-cell data clustering, with a particular focus on managing sparse, high-dimensional data.
View Article and Find Full Text PDFJ Expo Sci Environ Epidemiol
January 2025
Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milano, Italy.
Background: The Observed Individual Means (OIM) methodology, based on the non-parametric bootstrap, is usually employed to perform basic probabilistic dietary chronic exposure assessment, and assumes independence and identical distribution of occurrence data within food category. However, this assumption may not be valid if several expected distributions of occurrence can be a priori identified within food category. Moreover, OIM assumes each analysed food sample to equally contribute to mean occurrence, as information about relevance of each food item cannot be incorporated into exposure assessment.
View Article and Find Full Text PDFValue Health
January 2025
RTI Health Solutions, Manchester, UK. Electronic address:
Objectives: Several trial-level surrogate methods have been proposed in the literature. However, often only one method is presented in practice. By plotting trial-level associations between surrogate and final outcomes with prediction intervals and by presenting results from cross-validation procedures, this research demonstrates the value of comparing a range of model predictions.
View Article and Find Full Text PDFInt J Pharm
January 2025
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address:
In recent years, continuous manufacturing (CM) has become increasingly popular in the pharmaceutical industry for the production of oral solid dosage (OSD) forms. Most of the newly developed active pharmaceutical ingredients (APIs) nowadays are extremely cohesive and sticky with a mean particle size particle of <100μm, a wide particle size distribution (PSD) and a high tendency to agglomerate, making them difficult to accurately dose using loss-in-weight equipment during CM. In this research paper, the effect of various glidants on the volumetric and gravimetric feeding of several APIs was assessed.
View Article and Find Full Text PDFJ Mycol Med
January 2025
Mycology Laboratory, School of Pharmacy, Midwestern Paraná State University, UNICENTRO, PR, Brazil. Electronic address:
Bloodstream infection in neonates is a complicated disease and presents a major challenge both in diagnosis and in therapeutic intervention. The focus of the present study was to investigate the incidence, the species distribution and the risk factors associated with mortality of bloodstream infections in a neonatal intensive care unit (NICU) and evaluating the antifungal susceptibility of traditional antifungal drugs and three nanoparticle-based drug delivery systems based on nanoparticles. A total of 458 patients were evaluated, and 9.
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