The distribution of CD8+ phenotype (cytotoxic/suppressor) T lymphocytes in Peyer's patches and intestinal lamina propria in young adult (3-6 months) and old (24-29 months) Fischer 344 rats was examined using immunohistochemical and flow cytometric analyses. Flow cytometric analysis confirmed previous reports indicating no change with age in the proportion of Peyer's patch CD8+ cells in the rat. Immunohistochemical analysis showed discrete zones of densely stained CD8+ cells in the interfollicular areas and weakly stained cells within the follicles in Peyer's patches in young adult animals. In old rats, the number of intensely stained CD8+ cells between the follicles was markedly reduced and positively stained cells were distributed throughout the Peyer's patches. In addition, the population density of CD8+ cells is more diffuse in old animals, the number of CD8+ lymphocytes in the intestinal lamina propria increased 2.5-fold with aging from 533 +/- 59 cells/mm2 in young adult to 1312 +/- 83 cells/mm2 in old rats. The findings suggest that CD8+ cell distribution in the inductive and effector sites of gut associated lymphoid tissue undergoes age-related shifts.
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