A young adult male, ASA status I, presented for left shoulder arthroscopy. His medications included indocin for shoulder pain and chloroquine, an antimalarial. He was anesthetized using propofol, midazolam, fentanyl, and a relaxant. His initial oximetry reading of 94% saturation was erroneously attributed to shivering and to the fact that the oximeter clip was distal to the blood pressure cuff on the right upper extremity, necessitated by proximity of surgery. The initial saturation level of 94% was persistent throughout the case. The methemoglobin level drawn immediately postoperatively was 9%. The patient was treated with methylene blue which resulted in an improvement in oxygen saturation to 98%. His remaining postoperative course was uneventful, and he was released one day later.
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Cureus
June 2024
Internal Medicine, Henry Ford Jackson Hospital, Jackson, USA.
Methemoglobinemia is a condition characterized by the presence of abnormal hemoglobin, known as methemoglobin, in the blood, which impairs the ability of red blood cells to carry oxygen effectively. Symptoms include cyanosis, shortness of breath, fatigue, and in severe cases, organ damage or death. We presented a case of a 49-year-old female with multiple myeloma who developed drug-induced methemoglobinemia while on dapsone prophylaxis for Pneumocystis carinii pneumonia (PCP).
View Article and Find Full Text PDFRev Med Interne
August 2024
Service de réanimation chirurgicale, CHU de Rouen, 76000 Rouen, France.
Methemoglobinemia (MetHb) refers to the state of oxidation of the iron ion "ferrous" (Fe to iron "ferric" (Fe) within the heme molecule that makes up hemoglobin (Hb). This state is physiological if its level remains controlled. The ferrous state of the heme molecule occurs in the event of significant oxidative stress.
View Article and Find Full Text PDFCureus
April 2024
General Medicine, All India Institute of Medical Sciences, Nagpur, IND.
Acquired methemoglobinemia (MetHb) is a rare but potentially life-threatening condition that has varied etiology, usually toxin- or drug-induced. We had five cases of acquired methemoglobinemia during six months. Their presentation varied from an asymptomatic state to respiratory distress.
View Article and Find Full Text PDFAnasthesiol Intensivmed Notfallmed Schmerzther
December 2023
Drug-induced methemoglobinemia is a well-known phenomenon as well as induction by poppers (alcylnitrites substance group). Usually, suspicion is thrown in the right direction by a thorough medical history and environmental survey. But if intoxication is unintended and happens within the very private environment diagnosis might be very tricky.
View Article and Find Full Text PDFAnn Hematol
September 2024
Department of Hematology and Medical Oncology, Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY, USA.
Since the FDA's approval of rasburicase use for treatment of tumor lysis syndrome (TLS), multiple cases of rasburicase-induced methemoglobinemia and hemolytic anemia have been reported among patients with G6PD deficiency. This study aims to provide a systematic review of cases reporting such adverse reactions to rasburicase. A literature review of published cases in PubMed, Embase, Cochrane, and Web of Science was conducted.
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