The activity of dihydrofolate dehydrogenase by histochemical method in children leukocytes was investigated. Blood leukocytes have a positive enzymic activity. Except monocytes a large enzymic variability was observed in neutrophils, eosinophils, and lymphocytes in puberty and at the onset of the adolescence. Enzymic activity varies with blood cellular type, the age, in males and females and from one child to another.
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