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Could MOTS-C Levels in Children with Type 1 Diabetes Mellitus Be an İndicator for Early Diabetic Kidney Disease?
J Clin Res Pediatr Endocrinol
December 2024
Department of Pediatric Nephrology and Rheumatology, University of Canakkale Onsekiz Mart, Çanakkale, Turkey.
Objective: The aim of our study was to compare serum MOTS-c levels in children with Type 1 diabetes mellitus (T1DM) to those of healthy children. We also aimed to examine whether serum MOTS-c levels could be used as an early indicator of DKD by correlating with changes in GFR and microalbuminuria.
Methods: We recruited 82 patients who were being treated for insulin-dependent diabetes at the outpatient pediatric endocrinology clinic.
The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease.
Sci Transl Med
September 2023
Harvard Medical School and Division of Nephrology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Soluble urokinase plasminogen activator receptor (suPAR) is a risk factor for kidney diseases. In addition to suPAR, proteolysis of membrane-bound uPAR results in circulating D1 and D2D3 proteins. We showed that when exposed to a high-fat diet, transgenic mice expressing D2D3 protein developed progressive kidney disease marked by microalbuminuria, elevated serum creatinine, and glomerular hypertrophy.
View Article and Find Full Text PDFUsefulness of Doppler ultrasound for the early diagnosis of diabetic nephropathy in type 1 diabetes mellitus.
J Ultrasound
March 2022
Neonatal & Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Purpose: Early diagnosis and management of diabetic nephropathy (DN) might prevent or delay its progression to end-stage renal disease. The purpose of this study was to investigate whether changes in the duplex Doppler resistivity index (RI) are useful for the early identification of renal involvement in children and adolescents with insulin-dependent diabetes mellitus and associated conditions.
Materials And Methods: A total of 49 diabetic patients (two groups: 21 with DN and 28 without DN) were included in this study.
Implementation of Electronic Medical Record Template Improves Screening for Complications in Children with Type 1 Diabetes Mellitus.
Pediatric Health Med Ther
July 2020
New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY 11215, USA.
Objective: Health professionals and patients should follow comprehensive screening guidelines to recognize early signs of long-term complications for insulin-dependent type 1 diabetes mellitus (T1DM). The aim of this study is to demonstrate that utilization of electronic medical record (EMR) templates for diabetes management improves adherence to International Society for Pediatric and Adolescent Diabetes (ISPAD) screening guidelines.
Methods: All patients with T1DM who were seen in the outpatient pediatric endocrine clinic (age 0-22 years old) at an urban community-based community hospital during the 2014 calendar year were enrolled in the study (n=49).
Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study.
Pediatr Nephrol
August 2019
Department of Pediatrics, Division of Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Background: Renal damage is a progressive complication of sickle cell disease (SCD). Microalbuminuria is common in children with SCD, while a smaller number of children have more severe renal manifestations necessitating kidney biopsy. There is limited information on renal biopsy findings in children with SCD and subsequent management and outcome.
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