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Giant Duodenal Brunneroma: Report of a Rare Case and Review of the Literature.
Am J Case Rep
December 2024
Department of Visceral Surgery, Hospital of the Canton of St. Gallen, St. Gallen, Switzerland.
BACKGROUND Brunneromas are among the rarest benign tumors of the upper gastrointestinal tract. They arise from the Brunner's glands and patients have a good prognosis if treated timely and radically. Because symptoms are rare, their diagnosis can be challenging, especially regarding the smaller ones.
View Article and Find Full Text PDFMultiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes.
Blood Cancer Discov
November 2024
Clinical Genetics Service, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Article Synopsis
- First-degree relatives of multiple myeloma patients have a higher risk for the disease, yet the role of genetic variants in hereditary cancer genes remains unclear.
- A study analyzed germline exomes from nearly 1,700 multiple myeloma patients, identifying pathogenic variants in about 8.6-11.5% of cases, particularly in DNA repair genes like BRCA1 and BRCA2.
- The findings suggest that around 10% of multiple myeloma patients may have an undiagnosed cancer predisposition syndrome, indicating the importance of considering genetic testing for younger patients or those with a family cancer history to inform treatment options.
Possible transmission of Plasmodium malariae through liver transplantation: Diagnosis with a Sysmex XN-20™ hematology analyzer.
Parasitol Int
December 2024
Department of Clinical Analysis, La Fe University and Polytechnic Hospital, Avinguda Fernando Abril Martorell, 106, 46026, Valencia, Spain.
Malaria is an infectious disease caused by several species of the genus Plasmodium. It is usually transmitted by female Anopheles mosquitoes. Other routes of transmission include mother-to-child transmission, shared use of needles, blood transfusion and solid organ transplantation.
View Article and Find Full Text PDFGraft choice in pancreatectomy with vascular resection: equivalent safety in selected patients.
J Gastrointest Surg
November 2024
Department of Surgery, University of California, San Francisco, CA, United States; Section of Hepatopancreaticobiliary Surgery, Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, CA, United States; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, United States. Electronic address:
Background: Pancreatic cancer is the third leading cause of cancer-related death in the United States, with surgical resection being the only option for long-term survival. The ability to manage vascular involvement has expanded the pool of patients who are able to undergo resection with curative intent. However, not all vascular involvements can be detected preoperatively.
View Article and Find Full Text PDFInsights into docking in megasynthases from the investigation of the toblerol -AT polyketide synthase: many α-helical means to an end.
RSC Chem Biol
July 2024
Université de Lorraine, CNRS, IMoPA F-54000 Nancy France
The fidelity of biosynthesis by modular polyketide synthases (PKSs) depends on specific moderate affinity interactions between successive polypeptide subunits mediated by docking domains (DDs). These sequence elements are notably portable, allowing their transplantation into alternative biosynthetic and metabolic contexts. Herein, we use integrative structural biology to characterize a pair of DDs from the toblerol -AT PKS.
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