We examined whether optokinetic stimulation (OKS) affects balance recovery in an unexpected forward fall. Ten healthy male subjects participated in the study. Each was held in an initial, leaning-forward position supported by a cable connected to a strong magnet which enable unpredicted release. Instruction was given to move against forward fall by taking steps. To evaluate the relation between OKS velocities and balance recovery, ten stages of OKS velocities ranging from -100 (upward) degree/sec to +100 (downward) degree/sec were presented randomly. Balance recovery against forward fall was characterized by the reaction time, heel off, maximum vertical push, and heel contact. The latencies of these events decreased as the downward velocity of OKS increased; the latencies increased with the increment in the upward velocity of OKS. Changes in the latencies of the parameters took place in the early phase, in which the parameters of balance recovery depended little on the proprioceptive afferents from the lower limbs. This suggests that vection induced by the OKS affected the condition of the motor program which controls the initiation of the motor response. In other words, information from the visual system may modulate the condition of the motor program before the onset of movement.
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http://dx.doi.org/10.1016/0168-0102(93)90015-i | DOI Listing |
Sci Rep
December 2024
Department of Neuroscience and Padova Neuroscience Center, Università di Padova, Padova, Italy.
Can focal brain lesions, such as those caused by stroke, disrupt critical brain dynamics? What biological mechanisms drive its recovery? In a recent study, we showed that focal lesions generate a sub-critical state that recovers over time in parallel with behavior (Rocha et al., Nat. Commun.
View Article and Find Full Text PDFBAY 2413555 is a novel selective and reversible positive allosteric modulator of the type 2 muscarinic acetylcholine (M2) receptor, aimed at enhancing parasympathetic signaling and restoring cardiac autonomic balance for the treatment of heart failure (HF). This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms.
View Article and Find Full Text PDFWorld J Gastrointest Surg
December 2024
Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China.
Background: Endoscopic resection (ER) and laparoscopic resection (LR) have been widely used for the treatment of non-metastatic gastric gastrointestinal stromal tumors (gGISTs) (2-5 cm), but there are no selection criteria for their application.
Aim: To provide a reference for the development of standardized treatment strategies for gGISTs.
Methods: Clinical baseline characteristics, histopathological results, and short-term and long-term outcomes of patients who treated with ER or LR for gGISTs of 2-5 cm in Taizhou Hospital of Zhejiang Province from January 2014 to August 2022 were retrospectively reviewed.
Sci Rep
December 2024
Laboratory of Biochemistry and Vascular Biology, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, 20993, MD, USA.
Blood storage lesion induces cytosolic and membrane changes driven in part by hemoglobin (Hb) oxidation reactions within red blood cells (RBCs). A novel gel formulation containing the antioxidant curcuminoids in a biocompatible solvent system was used to deliver curcumin into RBCs. Incubation of peroxide treated RBCs stored in PBS with curcumin gel led to a reduction in prooxidant ferrylHb and recovery in ATP.
View Article and Find Full Text PDFPlant Physiol Biochem
December 2024
College of Agronomy, Jilin Agricultural University, 2888 Xincheng St, Changchun, 130118, Jilin, PR China; Institute of Agricultural Resource and Environment, Jilin Academy of Agricultural Sciences, 1363 Shengtai St, Changchun, 130033, Jilin, PR China. Electronic address:
Extreme conditions, such as cold and high humidity in northeast China's high-latitude maize region, can hinder crop yield and stability during the vegetative stage. However, there is a paucity of research examining the effects of simultaneous cold and high humidity stress on plant responses. In this study, we characterized the acclimation of JD558 (cold- and high humidity-sensitive hybrid) and JD441 (cold- and high humidity-tolerant hybrid) to stress at sowing caused by cold (4 °C), high humidity (25%), and their combined stress for five days, using physiological measurements and metabolomics during the stress treatments and recovery stages.
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