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A tactfully designed photothermal agent collaborating with ascorbic acid for boosting maxillofacial wound healing.
Natl Sci Rev
February 2025
Department of Oral Implantology, The Affiliated Stomatological Hospital of Nanjing Medical University. State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases. Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China.
Maxillofacial injuries that may cause severe functional and aesthetic damage require effective and immediate management due to continuous exposure to diverse microbial populations. Moreover, drug resistance, biofilm formation, and oxidative stress significantly impede timely bacterial removal and immune function, making the exploration of advanced materials for maxillofacial wound healing an appealing yet highly challenging task. Herein, a near-infrared photothermal sterilization agent was designed, encapsulated with liposomes and coated with ascorbic acid known for its antioxidant and immune-regulatory functions.
View Article and Find Full Text PDFCD11c-Expressing Microglia Are Transient, Driven by Interactions With Apoptotic Cells.
Glia
January 2025
Department of Neurobiology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Microglia, the parenchymal macrophage of the central nervous system, serve crucial remodeling functions throughout development. Microglia are transcriptionally heterogenous, suggesting that distinct microglial states confer discrete roles. Currently, little is known about how dynamic these states are, the cues that promote them, or how they impact microglial function.
View Article and Find Full Text PDFTargeting Dormant Disseminated Tumor Cells and their Permissive Niche by Pro-Resolving Mediators Derived from Resolution-Phase Macrophages.
Cancer Lett
January 2025
Department of Human Biology, University of Haifa, Haifa, Israel. Electronic address:
Metastatic breast cancer (BC) can recur years after initial treatments and arise from quiescent disseminated tumor cells (QDTC) that resist conventional therapies. To date there are no treatments to target QDTCs. Previously, the fibrotic-like niche (FLN) enriched with Type I collagen (Col-I) was shown to be required for the switch of QDTC to overt metastases.
View Article and Find Full Text PDFKetogenesis nutritionally supports brain during bacterial infection in Drosophila.
Brain Behav Immun
January 2025
University of South Bohemia, Faculty of Sciences, Department of Molecular Biology and Genetics, Ceske Budejovice, Czech Republic. Electronic address:
Mounting an immune response is a nutritionally demanding process that requires the systemic redistribution of energy stores towards the immune system. This is facilitated by cytokine-induced insulin resistance, which simultaneously promotes the mobilization of lipids and carbohydrates while limiting their consumption in immune-unrelated processes, such as development, growth, and reproduction. However, this adaptation also restricts the availability of nutrients to vital organs, which must then be sustained by alternative fuels.
View Article and Find Full Text PDFAn emodin-mediated multifunctional nanoplatform with augmented sonodynamic and immunoregulation for osteomyelitis therapy.
J Colloid Interface Sci
January 2025
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032 China; Shanxi Provincial Key Laboratory for Translational Nuclear Medicine and Precision Protection, Taiyuan 030006 China. Electronic address:
Emodin (ED), as a traditional Chinese medicine, possesses a variety of biological activities and is also one of natural sonosensitizer. Whether emodin could react with titanium dioxide to enhance the sonodynamic activity for safely treating osteomyelitis remains to be explored. Hence, an ED-conjugated Mn-doped titanium dioxide (TOM) nanorod array is designed and prepared on titanium to eliminate bacterial infections under ultrasound (US) treatment.
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