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Novel sensory trigger for gastrocolonic response.
Neurogastroenterol Motil
May 2023
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Background: Gastrocolonic response (GCR) is a physiologic increase in motor activity of the colon following meal ingestion. The presence of GCR, in colonic manometry (CM) studies, is used as a marker of normal colonic motor activity. Our aim was to investigate whether GCR could be induced by sensory stimulation (visual or olfactory) prior to food ingestion, and to describe the characteristics of patients with this response.
View Article and Find Full Text PDFEffect of Caffeine on Colonic Manometry in Children.
J Pediatr Gastroenterol Nutr
January 2023
From the Orlando Health Arnold Palmer Hospital for Children, Orlando, FL.
Objectives: Coffee and caffeinated products have been widely consumed for many centuries. Previous adult studies have suggested that both coffee and decaffeinated beverages induce colonic motility. However, no study has been conducted in pediatrics, and the role of caffeine alone in pediatric colonic motility needs to be explored.
View Article and Find Full Text PDFGastrocolonic Response.
Curr Gastroenterol Rep
November 2022
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA.
Purpose Of Review: The gastrocolonic response (GCR), is a physiologic increase in motor activity of the colon, which usually occurs within minutes following meal ingestion. Over the years several triggers that provoke GCR were recognized including gastric dilation, caloric intake, and fat component of the meal. The response is mediated by the vagal nerve and neurohumoral mechanisms, and it can be modified by several pharmacological factors.
View Article and Find Full Text PDFMelanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation.
Dig Dis Sci
August 2022
Division of Gastroenterology, Department of Pediatrics, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.
Background: Sennosides are commonly used for the treatment of constipation and associated with melanosis coli. In the present study, we evaluated the utility of melanosis coli as a marker of severity and its association with colonic motility in children with functional constipation.
Methods: Prospective study includes pediatric patients undergoing colonic manometry and colonic biopsies.
Evaluation of Fecal Incontinence in Pediatric Functional Constipation: Clinical Utility of Anorectal and Colon Manometry.
J Pediatr Gastroenterol Nutr
March 2021
Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School.
Objectives: The aim of the study is to evaluate the utility of motility studies in pediatric functional constipation with/without fecal incontinence.
Patients And Methods: Patients with functional constipation and failure to conventional therapy undergoing colonic manometry (CM) and/or anorectal manometry (ARM) manometry were classified as functional constipation without fecal incontinence (FC) or with fecal incontinence (FCI). Clinical data, motility parameters, and treatment outcomes were compared.
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