Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20-30 kDa proteins partially purified from pig brain (NTlm) cross-reacting with antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10(-6)-10(-8) M. Modification of Cys residues significantly reduced cytotoxicity of NT II. Both NT2 and NTlm induced apoptosis in L929 and K562 cells.
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| http://dx.doi.org/10.1016/0014-5793(94)80165-7 | DOI Listing |
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